ZFIN ID: ZDB-GENE-080225-35
Gene Name: formin 2b
Gene Symbol: fmn2b    Nomenclature History

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Previous Name: im:7158925

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have microtubule binding activity. Predicted to be involved in formin-nucleated actin cable assembly and intracellular transport. Predicted to localize to cytoplasm; endoplasmic reticulum membrane; and nucleus. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human FMN2 (formin 2).
Genome Resources: Alliance (1),  Gene:566432 (1),  Ensembl(GRCz11):ENSDARG00000061778 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (7 images) from Thisse et al., 2004 [IMAGE:7158925]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018308Tg Transgenic Insertion Unknown Unknown DNA
PHENOTYPE No data available
DISEASE ASSOCIATED WITH fmn2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mental retardation, autosomal recessive 47 616193
DISEASE ASSOCIATED WITH fmn2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process actin nucleation (more)
Cellular Component actin filament (more)
Molecular Function microtubule binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA fmn2b-202 (1)    Ensembl 5336
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM fmn2b No data available
MARKER RELATIONSHIPS
fmn2b Contained in: [BAC] CH73-367A6 (1)
fmn2b Encodes: [EST] IMAGE:7158925 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_009306989 (1)
Genomic GenBank:CU607101 (1) 119244 nt
Select Tool
Polypeptide UniProtKB:A0A2R8QAK8 (1) 1479 aa
Sequence Information (all 14)
ORTHOLOGY for fmn2b ( Chr: 12 )
CITATIONS (21)