Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-080225-11
Gene Name: Wolfram syndrome 1a (wolframin)
Gene Symbol: wfs1a
Previous Names: wfs1, im:7153058 (1), si:dkey-228b21.2
Location: Chr: 1   Details
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (5 images) from Thisse et al., 2004 [IMAGE:7153058]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
  myotome
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa10021, sa11465
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Deafness, autosomal dominant 6/14/38 600965
Wolfram syndrome 222300
Wolfram-like syndrome, autosomal dominant 614296
?Cataract 41 116400
{Diabetes mellitus, noninsulin-dependent, association with} 125853
GENE ONTOLOGY
Ontology GO Term
Biological Process calcium ion homeostasis (more)
Cellular Component endoplasmic reticulum (more)
Molecular Function molecular_function (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011990 (1)
  • InterPro:IPR026208 (1)
  • InterPro:IPR026209 (1)
  •  Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM wfs1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    wfs1a Contained in: [BAC] DKEY-228B21 (1)
    wfs1a Encodes: [EST] IMAGE:7153058 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_690160 (1) 3801 bp
    Genomic GenBank:BX530018 (1) 221617 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7F259 (1) 1061 aa
    Sequence Clusters UniGene:88234 (1)
    Sequence Information (all 13)
    OTHER wfs1a GENE PAGES
  • Gene:566876 (1)
  • Ensembl(Zv9):ENSDARG00000062341 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish wfs1a 1  
    Human WFS1 4 (4p16.1)
  • OMIM:606201
  • Gene:7466
  • Mouse Wfs1 5 ( 19.46 cM)
  • MGI:1328355
  • Gene:22393
  • Orthology Details
    CITATIONS (12)