ZFIN ID: ZDB-GENE-080225-11
Gene Name: Wolfram syndrome 1a (wolframin)
Gene Symbol: wfs1a
Previous Names: wfs1, im:7153058 (1), si:dkey-228b21.2
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (5 images) from Thisse et al., 2004 [IMAGE:7153058]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
  myotome
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10021 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11465 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH wfs1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness Deafness, autosomal dominant 6/14/38 600965
    cataract ?Cataract 41 116400
    type 2 diabetes mellitus {Diabetes mellitus, noninsulin-dependent, association with} 125853
    Wolfram syndrome Wolfram syndrome 222300
    Wolfram-like syndrome, autosomal dominant 614296
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion homeostasis (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function molecular_function (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011990 (1)
  • InterPro:IPR026208 (1)
  • InterPro:IPR026209 (1)
  •  Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM wfs1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    wfs1aContained in: [BAC] DKEY-228B21 (1) (order this)
    wfs1aEncodes: [EST] IMAGE:7153058 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_690160 (1) 3883bp
    Genomic GenBank:BX530018 (1) 221617bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7F259 (1) 1061aa
    Sequence Clusters UniGene:129951 (1)
    Sequence Information (all 13)
    OTHER wfs1a GENE PAGES
  • Gene:566876 (1)
  • Ensembl(GRCz10):ENSDARG00000062341 (1)
  • ORTHOLOGY for wfs1a (Chr: 1)
    Species Symbol Chromosome Accession # Evidence
    Human WFS1 4
  • Gene:7466
  • OMIM:606201
  • HGNC:12762
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Wfs1 5
  • MGI:1328355
  • Gene:22393
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (13)