ZFIN ID: ZDB-GENE-080225-11
Gene Name: Wolfram syndrome 1a (wolframin)
Gene Symbol: wfs1a
Previous Names: wfs1, im:7153058 (1), si:dkey-228b21.2
Location: Chr: 1   Details
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (5 images) from Thisse et al., 2004 [IMAGE:7153058]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
  myotome
MUTANTS AND TARGETED KNOCKDOWNS

Allele Type Mutagen Suppliers
sa10021 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11465 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Phenotype of Human Orthologue OMIM Phenotype ID
    Deafness, autosomal dominant 6/14/38 600965
    Wolfram syndrome 222300
    Wolfram-like syndrome, autosomal dominant 614296
    ?Cataract 41 116400
    {Diabetes mellitus, noninsulin-dependent, association with} 125853
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion homeostasis (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function molecular_function (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011990 (1)
  • InterPro:IPR026208 (1)
  • InterPro:IPR026209 (1)
  •  Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM wfs1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    wfs1a Contained in: [BAC] DKEY-228B21 (1) (order this)
    wfs1a Encodes: [EST] IMAGE:7153058 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_690160 (1) 3535 bp
    Genomic GenBank:BX530018 (1) 221617 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7F259 (1) 1061 aa
    Sequence Clusters UniGene:129951 (1)
    Sequence Information (all 13)
    OTHER wfs1a GENE PAGES
  • Gene:566876 (1)
  • Ensembl(Zv9):ENSDARG00000062341 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish wfs1a 1  
    Human WFS1 4 (4p16.1)
  • OMIM:606201
  • Gene:7466
  • Mouse Wfs1 5 ( 19.46 cM)
  • MGI:1328355
  • Gene:22393
  • Orthology Details
    CITATIONS (12)