ZFIN ID: ZDB-GENE-080220-52
Gene Name: sharpin and rbck1 related
Gene Symbol: shrprbck1r    Nomenclature History

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Previous Names: sipl1-rbck1 (1), zgc:175152

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have ubiquitin binding activity and ubiquitin-protein transferase activity. Involved in embryonic cranial skeleton morphogenesis and otic vesicle morphogenesis. Predicted to localize to the LUBAC complex. Is expressed in inner ear; midbrain hindbrain boundary; otic vesicle; and pharyngeal arch. Orthologous to human SHARPIN (SHANK associated RH domain interactor).
Genome Resources: Alliance (1),  Gene:569903 (1),  Ensembl(GRCz11):ENSDARG00000059871 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7080 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-shrprbck1r N/A 1
MO2-shrprbck1r N/A 1
DISEASE ASSOCIATED WITH shrprbck1r HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH shrprbck1r VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process embryonic cranial skeleton morphogenesis (more)
Cellular Component LUBAC complex (more)
Molecular Function ubiquitin binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001841 Zinc finger, RING-type
Domain IPR001876 Zinc finger, RanBP2-type
Domain IPR002867 IBR domain
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Conserved_site IPR017907 Zinc finger, RING-type, conserved site
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Domain IPR031912 Sharpin, PH domain
Homologous_superfamily IPR036443 Zinc finger, RanBP2-type superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA shrprbck1r-201 (1)    Ensembl 4393
shrprbck1r-202 (1)    Ensembl 3884
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM shrprbck1r No data available
MARKER RELATIONSHIPS
shrprbck1r Contained in: [BAC] CH73-174H16 (1)
shrprbck1r Encodes: [cDNA] MGC:175152 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001111200 (1) 3172 bp
Genomic GenBank:CU695007 (1) 91354 bp
Select Tool
Polypeptide UniProtKB:A9JTG5 (1) 714 aa
Sequence Information (all 14)
ORTHOLOGY for shrprbck1r ( Chr: 7 )
CITATIONS (16)