ZFIN ID: ZDB-GENE-080220-37
Gene Name: potassium voltage-gated channel, KQT-like subfamily, member 2a
Gene Symbol: kcnq2a    Nomenclature History

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Previous Name: zgc:171872

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have calmodulin binding activity and delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to localize to axon initial segment and voltage-gated potassium channel complex. Is expressed in central nervous system; heart; and inner ear. Human ortholog(s) of this gene implicated in benign neonatal seizures and early infantile epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2).
Genome Resources: Alliance (1),  Gene:100141342 (1),  Ensembl(GRCz11):ENSDARG00000075307 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa492 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21297 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44687 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kcnq2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    benign neonatal seizures Alliance Myokymia 121200
    Seizures, benign neonatal, 1 121200
    early infantile epileptic encephalopathy 7 Alliance Epileptic encephalopathy, early infantile, 7 613720
    DISEASE ASSOCIATED WITH kcnq2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kcnq2a-202 (1)    Ensembl 2679
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kcnq2a No data available
    MARKER RELATIONSHIPS
    kcnq2a Contained in: [BAC] DKEY-183P4 (1) (order this)
    kcnq2a Encodes: [cDNA] MGC:171872 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001114907 (1) 1282 nt
    Genomic GenBank:CR847543 (1) 207382 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B8JIR6 (1) 883 aa
    Sequence Information (all 11)
    ORTHOLOGY for kcnq2a ( Chr: 8 )
    CITATIONS (19)