ZFIN ID: ZDB-GENE-080219-34
Gene Name: mitogen-activated protein kinase kinase 2b
Gene Symbol: map2k2b    Nomenclature History

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Previous Name: zgc:172250

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have MAP kinase kinase activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including activation of MAPK activity; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2).
Genome Resources: Alliance (1),  Gene:100002225 (1),  Ensembl(GRCz11):ENSDARG00000068918 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH map2k2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cardiofaciocutaneous syndrome 4 Alliance Cardiofaciocutaneous syndrome 4 615280
DISEASE ASSOCIATED WITH map2k2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process phosphorylation (more)
Molecular Function ATP binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA map2k2b-203 (1)    Ensembl 2466
ncRNA map2k2b-002 (1)    Ensembl 1051
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM map2k2b No data available
MARKER RELATIONSHIPS
map2k2b Contained in: [BAC] DKEY-201N22 (1) (order this)
map2k2b Encodes: [cDNA] MGC:172250 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001128281 (1) 2460 nt
Genomic GenBank:CR391909 (1) 158411 nt
Select Tool
Polypeptide UniProtKB:A9JRF0 (1) 395 aa
Sequence Information (all 14)
ORTHOLOGY for map2k2b ( Chr: 2 )
CITATIONS (17)