ZFIN ID: ZDB-GENE-080218-30
Gene Name: glutathione S-transferase mu tandem duplicate 2
Gene Symbol: gstm.2    Nomenclature History

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Previous Name: zgc:173994

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have glutathione transferase activity. Predicted to be involved in glutathione metabolic process and xenobiotic catabolic process. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in several diseases, including eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple). Is expressed in brain; gill; liver; and pleuroperitoneal region. Orthologous to several human genes including GSTM4 (glutathione S-transferase mu 4).
Genome Resources: Alliance (1),  Gene:571365 (1),  Ensembl(GRCz11):ENSDARG00000029473 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41207 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gstm.2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH gstm.2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process glutathione metabolic process (more)
    Molecular Function glutathione transferase activity (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR003081 Glutathione S-transferase, Mu class
    Domain IPR004045 Glutathione S-transferase, N-terminal
    Domain IPR004046 Glutathione S-transferase, C-terminal
    Domain IPR010987 Glutathione S-transferase, C-terminal-like
    Homologous_superfamily IPR036249 Thioredoxin-like superfamily
    Homologous_superfamily IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gstm.2-201 (1)    Ensembl 1547
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gstm.2 No data available
    MARKER RELATIONSHIPS
    gstm.2 Contained in: [BAC] DKEY-183P4 (1) (order this)
    gstm.2 Encodes: [cDNA] MGC:173994 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001110116 (1) 1563 bp
    Genomic GenBank:CR847543 (1) 207382 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A8KBR8 (1) 219 aa
    Sequence Information (all 10)
    ORTHOLOGY for gstm.2 ( Chr: 8 )
    CITATIONS (21)