ZFIN ID: ZDB-GENE-080218-17
Gene Name: mitogen-activated protein kinase 8a
Gene Symbol: mapk8a    Nomenclature History

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Previous Names: jnk1a-2 (1), zgc:172209

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have JUN kinase activity. Predicted to be involved in JNK cascade and regulation of gene expression. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; benign rectal neoplasm; colorectal adenoma; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8).
Genome Resources: Alliance (1),  Gene:562720 (1),  Ensembl(GRCz11):ENSDARG00000031888 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018549Tg Transgenic Insertion Unknown Unknown DNA
la018550Tg Transgenic Insertion Unknown Unknown DNA
sa6311 Point Mutation Unknown Splice Site ENU
sa10069 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28135 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mapk8a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mapk8a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mapk8a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mapk8a-202 (1)    Ensembl 2211
    mapk8a-204 (1)    Ensembl 1796
    mapk8a-205 (1)    Ensembl 421
    ncRNA mapk8a-003 (1)    Ensembl 746
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mapk8a No data available
    MARKER RELATIONSHIPS
    mapk8a Contained in: [BAC] CH211-223A10 (1)
    mapk8a Encodes: [cDNA] MGC:172209 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001110389 (1) 1644 nt
    Genomic GenBank:CR931802 (1) 136909 nt
    Select Tool
    Polypeptide UniProtKB:A8WG58 (1) 427 aa
    Sequence Information (all 20)
    ORTHOLOGY for mapk8a ( Chr: 13 )
    CITATIONS (27)