ZFIN ID: ZDB-GENE-080211-1
Gene Name: NOVA alternative splicing regulator 2
Gene Symbol: nova2    Nomenclature History

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Previous Names: id:ibd1128, sb:cb364

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to localize to cytoplasm and nucleus. Is expressed in nervous system; neural plate; and posterior cardinal vein. Orthologous to human NOVA2 (NOVA alternative splicing regulator 2).
Genome Resources: Alliance (1),  Gene:553201 (1),  Ensembl(GRCz11):ENSDARG00000017673 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb364]
  2 figures (3 images) from Kudoh et al., 2001 [ibd1128]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
io011 Indel Exon 1 Premature Stop CRISPR
la010946Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012711Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la019291Tg Transgenic Insertion Unknown Unknown DNA
    la019292Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027630Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16605 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • uq14bh Insertion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nova2 1
    CRISPR2-nova2 1
    DISEASE ASSOCIATED WITH nova2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with or without autistic features and/or structural brain abnormalities 618859
    DISEASE ASSOCIATED WITH nova2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mRNA splicing, via spliceosome (more)
    Cellular Component cytoplasm (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nova2-201 (1)    Ensembl 1951
    nova2-203 (1)    Ensembl 8894
    ncRNA nova2-003 (1) 356
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nova2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(10xuas:nova2-2a-egfp,cryaa:egfp) cryaaUAS 2AEGFPnova2 Danio rerio 1 1
    tgbac(nova2:yfp) nova2 YFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    nova2 Contained in: [BAC] CH211-103O18 (1), CH211-225B7 (1)
    nova2 Encodes: [EST] cb364 (1) (order this), ibd1128
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001309524 (1)
    Genomic GenBank:BX088540 (1) 176569 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4ILY0 (1) 518 aa
    Sequence Information (all 22)
    ORTHOLOGY for nova2 ( Chr: 15 )
    CITATIONS (27)