ZFIN ID: ZDB-GENE-080204-82
Gene Name: cholesterol 25-hydroxylase like 2
Gene Symbol: ch25hl2    Nomenclature History

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Previous Names: ch25hd (1), zgc:175201

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have C-4 methylsterol oxidase activity and steroid hydroxylase activity. Predicted to be involved in cholesterol metabolic process and sterol biosynthetic process. Predicted to localize to endoplasmic reticulum membrane. Is expressed in gill; intestine; kidney; liver; and spleen. Orthologous to human CH25H (cholesterol 25-hydroxylase).
Genome Resources: Alliance (1),  Gene:100136851 (1),  Ensembl(GRCz11):ENSDARG00000038728 (2)
GENE EXPRESSION
All Expression Data: 2 figures from Pereiro et al., 2017
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43581 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ch25hl2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ch25hl2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lipid biosynthetic process (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function iron ion binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ch25hl2 No data available
    MARKER RELATIONSHIPS
    ch25hl2 Encodes: [cDNA] MGC:175201 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001114570 (1)
    Polypeptide UniProtKB:A0A223M0K5 (1) 279 aa
    Sequence Information (all 11)
    ORTHOLOGY for ch25hl2 ( Chr: 21 )
    CITATIONS (17)