header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-080204-119
Gene Name: heparin-binding EGF-like growth factor a
Gene Symbol: hbegfa    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:175091

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have epidermal growth factor receptor binding activity and growth factor activity. Involved in retina development in camera-type eye and sensory epithelium regeneration. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in perinatal necrotizing enterocolitis. Is expressed in retina. Orthologous to human HBEGF (heparin binding EGF like growth factor).
Genome Resources: Alliance (1),  Gene:797938 (1),  Ensembl(GRCz11):ENSDARG00000075121 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 6 publications
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns189 Small Deletion Exon 3 Premature Stop CRISPR
bns203 Small Deletion Unknown Unknown CRISPR
bns243 Small Deletion Unknown Unknown CRISPR
sa18135 Point Mutation Exon 3 Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31972 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42344 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hbegfa 1
    CRISPR2-hbegfa 1
    CRISPR3-hbegfa 1
    MO1-hbegfa N/A 3
    DISEASE ASSOCIATED WITH hbegfa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Diphtheria, susceptibility to}
    DISEASE ASSOCIATED WITH hbegfa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sensory epithelium regeneration (more)
    Cellular Component integral component of membrane (more)
    Molecular Function epidermal growth factor receptor binding (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hbegfa-201 (1)    Ensembl 1808
    ncRNA hbegfa-002 (1)    Ensembl 760
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hbegfa No data available
    MARKER RELATIONSHIPS
    hbegfa Contained in: [BAC] CH73-269I13 (1) (order this)
    hbegfa Encodes: [cDNA] MGC:175091 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001111226 (1) 1770 bp
    Genomic GenBank:CU855621 (1) 79189 bp
    Select Tool
    Polypeptide UniProtKB:A9JRW9 (1) 230 aa
    Sequence Clusters UniGene:16053 (1)
    Sequence Information (all 10)
    ORTHOLOGY for hbegfa ( Chr: 14 )
    CITATIONS (37)