Gene

il7r

ID
ZDB-GENE-080110-7
Name
interleukin 7 receptor
Symbol
il7r Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable cytokine receptor activity. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; myelination; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in T cell; brain; lymphoid progenitor cell; and thymus. Human ortholog(s) of this gene implicated in severe combined immunodeficiency and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human IL7R (interleukin 7 receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il7r Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive Alliance Severe combined immunodeficiency, T-cell negative, B-cell/natural killer cell-positive type 608971
Associated With il7r Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003531 Short hematopoietin receptor, family 1, conserved site
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Domain Details Per Protein
Protein Length Immunoglobulin-like fold Short hematopoietin receptor, family 1, conserved site
UniProtKB:E9QDP8 372
UniProtKB:A8WH87 334
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations