Gene

csf3r

ID
ZDB-GENE-080104-4
Name
colony stimulating factor 3 receptor (granulocyte)
Symbol
csf3r Nomenclature History
Previous Names
  • gcsfr (2)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have cytokine receptor activity and granulocyte colony-stimulating factor binding activity. Involved in hemopoiesis and positive regulation of hematopoietic progenitor cell differentiation. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in several structures, including heart; hematopoietic system; immune system; myeloid cell; and pleuroperitoneal region. Used to study neutropenia and severe congenital neutropenia. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With csf3r Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
severe congenital neutropenia 7 Alliance Neutropenia, severe congenital, 7, autosomal recessive 617014
Associated With csf3r Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Domain IPR003961 Fibronectin type III
Domain IPR010457 Immunoglobulin C2-set-like, ligand-binding
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin C2-set-like, ligand-binding Immunoglobulin-like domain superfamily Immunoglobulin-like fold Long hematopoietin receptor, Gp130 family 2, conserved site
UniProtKB:F1R904 810
UniProtKB:A8Y5W0 810
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations