ZFIN ID: ZDB-GENE-080104-4
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Gene Name: colony stimulating factor 3 receptor (granulocyte)
Gene Symbol: csf3r
Sequence Ontology ID : SO:0000704

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Previous Name: gcsfr (2)

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(Including Attributions)
Location: Chr: 16 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have interleukin-11 binding activity and interleukin-11 receptor activity; involved in animal organ development, hemopoiesis, and positive regulation of hematopoietic progenitor cell  ...
GENE EXPRESSION
All Expression Data: 17 figures from 11 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gl31 Small Deletion Unknown Unknown CRISPR
gl32 Indel Unknown Unknown CRISPR
gl34 Small Deletion Unknown Unknown CRISPR
sa36021 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa39077 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42647 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Targeting reagents:
    PHENOTYPE
    Data: 13 figures from 7 publications
    Observed in:
    DISEASE ASSOCIATED WITH csf3r HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Neutropenia, severe congenital, 7, autosomal recessive 617014
    DISEASE ASSOCIATED WITH csf3r VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    severe congenital neutropenia i114Tg + CRISPR1-csf3r + CRISPR2-csf3r + CRISPR3-csf3r standard conditions Pazhakh et al., 2017
    i114Tg + CRISPR3-csf3r standard conditions Pazhakh et al., 2017
    i114Tg + CRISPR2-csf3r standard conditions Pazhakh et al., 2017
    i114Tg + CRISPR1-csf3r standard conditions Pazhakh et al., 2017
    i114Tg + CRISPR1-csf3r + CRISPR2-csf3r standard conditions Pazhakh et al., 2017
    WT + CRISPR1-csf3r + CRISPR2-csf3r standard conditions Pazhakh et al., 2017
    WT + CRISPR1-csf3r + CRISPR3-csf3r standard conditions Pazhakh et al., 2017
    i114Tg + CRISPR1-csf3r + CRISPR3-csf3r standard conditions Pazhakh et al., 2017
    i114Tg + CRISPR2-csf3r + CRISPR3-csf3r standard conditions Pazhakh et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process granulocyte differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cytokine receptor activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003529 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR010457 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR036116 (1)
  • InterPro:IPR036179 (1)
    		•
  • PROSITE:PS01353 (1)
  • PROSITE:PS50853 (1)
    		•
  • Pfam:PF00041 (1)
  • Pfam:PF06328 (1)
    		•
    TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM csf3r No data available
    MARKER RELATIONSHIPSNo data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001113377 (1) 2433bp
    Select Tool
    Genomic GenBank:CABZ01043949 (1) 9311bp
    Select Tool
    Polypeptide UniProtKB:A8Y5W0 (1) 810aa
    Select Tool
    Sequence Clusters UniGene:142587 (1)
    Sequence Information (all 13)
    OTHER csf3r GENE PAGES
  • Alliance (1)
  • Gene:100134935 (1)
  • Ensembl(GRCz11):ENSDARG00000045959 (2)
    • ORTHOLOGY for csf3r (Chr: 16)
    CITATIONS (54)