Gene
csf3r
- ID
- ZDB-GENE-080104-4
- Name
- colony stimulating factor 3 receptor (granulocyte)
- Symbol
- csf3r Nomenclature History
- Previous Names
-
- gcsfr (2)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables molecular sequestering activity. Involved in cytokine-mediated signaling pathway. Acts upstream of or within hemopoiesis and positive regulation of hematopoietic progenitor cell differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Is expressed in several structures, including heart; hematopoietic system; immune system; myeloid cell; and pleuroperitoneal region. Used to study neutropenia and severe congenital neutropenia. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
hereditary neutrophilia | Alliance | ?Neutrophilia, hereditary | 162830 |
severe congenital neutropenia 7 | Alliance | Neutropenia, severe congenital, 7, autosomal recessive | 617014 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR003529 | Long hematopoietin receptor, Gp130 family 2, conserved site |
Domain | IPR003961 | Fibronectin type III |
Domain | IPR010457 | Immunoglobulin C2-set-like, ligand-binding |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin C2-set-like, ligand-binding | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Long hematopoietin receptor, Gp130 family 2, conserved site |
---|---|---|---|---|---|---|---|
UniProtKB:F1R904
|
810 | ||||||
UniProtKB:A8Y5W0
|
810 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available