ZFIN ID: ZDB-GENE-080104-4
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Gene Name: colony stimulating factor 3 receptor (granulocyte)
Gene Symbol: csf3r    Nomenclature History

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Previous Name: gcsfr (2)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have interleukin-11 binding activity and interleukin-11 receptor activity. Involved in hemopoiesis and positive regulation of hematopoietic progenitor cell differentiation. Predicted to localize to the external side of plasma membrane and receptor complex. Used to study severe congenital neutropenia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; chronic myelomonocytic leukemia; chronic neutrophilic leukemia; myelodysplastic syndrome; and severe congenital neutropenia. Is expressed in several structures, including heart; hematopoietic system; immune system; myeloid cell; and pleuroperitoneal region. Orthologous to human CSF3R (colony stimulating factor 3 receptor).
Genome Resources: Alliance (1),  Gene:100134935 (1),  Ensembl(GRCz11):ENSDARG00000045959 (2)
GENE EXPRESSION
All Expression Data: 17 figures from 12 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gl31 Small Deletion Unknown Unknown CRISPR
gl32 Indel Unknown Unknown CRISPR
gl33 Small Deletion Unknown Unknown CRISPR
gl34 Small Deletion Unknown Unknown CRISPR
mdu5 Small Deletion Unknown Frameshift, Premature Stop TALEN
mdu6 Small Deletion Unknown Frameshift, Premature Stop TALEN
sa36021 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa39077 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42647 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-csf3r
    		1
    CRISPR2-csf3r
    		1
    CRISPR3-csf3r 1
    CRISPR4-csf3r
    		1
    CRISPR5-csf3r
    		1
    MO1-csf3r N/A 6
    MO2-csf3r N/A 2
    MO3-csf3r N/A 17
    MO4-csf3r N/A 3
    MO5-csf3r N/A 1
    TALEN1-csf3r 1
    PHENOTYPE
    Data: 19 figures from 10 publications
    Observed in:
    DISEASE ASSOCIATED WITH csf3r HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neutropenia, severe congenital, 7, autosomal recessive 617014
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process granulocyte differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cytokine receptor activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
    Domain IPR003961 Fibronectin type III
    Domain IPR010457 Immunoglobulin C2-set-like, ligand-binding
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR036116 Fibronectin type III superfamily
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM csf3r No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001113377 (1) 2433 bp
    Select Tool
    Genomic GenBank:CABZ01043949 (1) 9311 bp
    Select Tool
    Polypeptide UniProtKB:A8Y5W0 (1) 810 aa
    Select Tool
    Sequence Information (all 12)
    ORTHOLOGY for csf3r ( Chr: 16 )
    CITATIONS (61)