ZFIN ID: ZDB-GENE-080104-2
Gene Name: DnaJ (Hsp40) homolog, subfamily C, member 6
Gene Symbol: dnajc6    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have clathrin binding activity. Predicted to be involved in clathrin coat disassembly and clathrin-dependent endocytosis. Localizes to the cytosol and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Is expressed in hindbrain; inner ear; neural rod; otic vesicle; and spinal cord. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).
Genome Resources: Alliance (1),  Gene:796345 (1),  Ensembl(GRCz11):ENSDARG00000079891 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6069 Point Mutation Unknown Premature Stop ENU
sa17174 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17894 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dnajc6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Parkinson's disease 19A Alliance Parkinson disease 19a, juvenile-onset 615528
    Parkinson disease 19b, early-onset 615528
    DISEASE ASSOCIATED WITH dnajc6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process clathrin coat disassembly (more)
    Cellular Component cytosol (more)
    Molecular Function clathrin binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001623 DnaJ domain
    Domain IPR014020 Tensin phosphatase, C2 domain
    Domain IPR029023 Tensin-type phosphatase domain
    Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
    Homologous_superfamily IPR036869 Chaperone J-domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dnajc6-201 (1)    Ensembl 7250
    ncRNA dnajc6-002 (1)    Ensembl 560
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dnajc6 No data available
    MARKER RELATIONSHIPS
    dnajc6 Contained in: [BAC] CH211-157E20, DKEY-1K24 (order this), DKEY-202I2 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009302472 (1)
    Genomic RefSeq:NW_018395257 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QIA5 (1) 913 aa
    Sequence Information (all 45)
    ORTHOLOGY for dnajc6 ( Chr: 6 )
    CITATIONS (15)