ZFIN ID: ZDB-GENE-071219-1
Gene Name: neuroligin 3a
Gene Symbol: nlgn3a    Nomenclature History

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Previous Name: nlgn3b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to localize to the cell surface; integral component of plasma membrane; and synapse. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Is expressed in several structures, including brain; cranial ganglion; eye; gonad; and spinal cord. Orthologous to human NLGN3 (neuroligin 3).
Genome Resources: Alliance (1),  Gene:562702 (1),  Ensembl(GRCz11):ENSDARG00000104786 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018826Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018827Tg Transgenic Insertion Unknown Unknown DNA
    sa11831 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22451 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35667 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nlgn3a
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nlgn3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Asperger syndrome susceptibility, X-linked 1} 300494
    {Autism susceptibility, X-linked 1} 300425
    DISEASE ASSOCIATED WITH nlgn3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell adhesion (more)
    Cellular Component integral component of membrane (more)
    Molecular Function neurexin family protein binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000460 Neuroligin
    Domain IPR002018 Carboxylesterase, type B
    Conserved_site IPR019819 Carboxylesterase type B, conserved site
    Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
    Family IPR030024 Neuroligin-3
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nlgn3a-201 (1)    Ensembl 2754
    nlgn3a-202 (1)    Ensembl 4525
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nlgn3a No data available
    MARKER RELATIONSHIPS
    nlgn3a Contained in: [BAC] DKEY-21I17 (1) (order this), DKEY-27I16 (1) (order this), DKEY-30K5 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001166332 (1) 2448 bp
    Genomic GenBank:CR388144 (1) 211706 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IJ74 (1) 878 aa
    Sequence Information (all 26)
    ORTHOLOGY for nlgn3a ( Chr: 14 )
    CITATIONS (23)