Gene

nlgn3a

ID

ZDB-GENE-071219-1

Name

neuroligin 3a

Symbol

nlgn3a Nomenclature History

Previous Names

nlgn3b (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to localize to cell surface; integral component of plasma membrane; and synapse. Is expressed in several structures, including brain; cranial ganglion; eye; gonad; and spinal cord. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to human NLGN3 (neuroligin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nlgn3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Autism susceptibility, X-linked 1}	300425

Associated With nlgn3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019819	Carboxylesterase type B, conserved site
Domain	IPR002018	Carboxylesterase, type B
Family	IPR000460	Neuroligin
Family	IPR051093	Neuroligin and Bile salt-activated lipase
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold

Domain Details Per Protein

Protein	Length	Alpha/Beta hydrolase fold	Carboxylesterase, type B	Carboxylesterase type B, conserved site	Neuroligin	Neuroligin and Bile salt-activated lipase
UniProtKB:A0A8M9QB35 InterPro	858
UniProtKB:A0A0R4IJ74 InterPro	878
UniProtKB:A0A0R4IQV1 InterPro	838
UniProtKB:D0EVX1 InterPro	815

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nlgn3a-201 (1) Ensembl	Ensembl	2,754 nt	Select Tool
mRNA	nlgn3a-202 (1) Ensembl	Ensembl	4,525 nt	Select Tool
mRNA	nlgn3a-203 (1) Ensembl	Ensembl	3,367 nt	Select Tool ZFIN BLAST
mRNA	nlgn3a-204 (1) Ensembl	Ensembl	3,307 nt	Select Tool ZFIN BLAST
mRNA	nlgn3a-205 (1) Ensembl	Ensembl	2,448 nt	Select Tool ZFIN BLAST
mRNA	nlgn3a-206 (1) Ensembl	Ensembl	3,307 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations