ZFIN ID: ZDB-GENE-071212-3
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: FLII actin remodeling protein
Gene Symbol: flii    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: im:7141769

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Involved in sarcomere organization. Is expressed in myotome. Orthologous to human FLII (FLII actin remodeling protein).
Genome Resources: Alliance (1),  Gene:560281 (1),  Ensembl(GRCz11):ENSDARG00000059701 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7141769]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mi372 Point Mutation Acceptor Splice Site of Exon 5 Premature Stop ENU
sa9399 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa12788 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-flii N/A 1
    PHENOTYPE
    Data: 4 figures from Naganawa et al., 2011
    Observed in:
    DISEASE ASSOCIATED WITH flii HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH flii VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sarcomere organization (more)
    Cellular Component cellular_component (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Repeat IPR001611 Leucine-rich repeat
    Repeat IPR003591 Leucine-rich repeat, typical subtype
    Family IPR007122 Villin/Gelsolin
    Domain IPR007123 Gelsolin-like domain
    Repeat IPR025875 Leucine rich repeat 4
    Homologous_superfamily IPR029006 ADF-H/Gelsolin-like domain superfamily
    Family IPR029919 Protein flightless-1
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    Homologous_superfamily IPR036180 Gelsolin-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA flii-201 (1)    Ensembl 5403
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM flii No data available
    MARKER RELATIONSHIPS
    flii Contained in: [BAC] DKEY-19E10 (1) (order this)
    flii Encodes: [EST] IMAGE:7141769 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001257146 (1) 3878 bp
    Select Tool
    Genomic GenBank:BX649547 (1) 237569 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F8WK50 (1) 1259 aa
    Select Tool
    Sequence Information (all 10)
    ORTHOLOGY for flii ( Chr: 3 )
    CITATIONS (20)