Gene

itgb3b

ID
ZDB-GENE-071207-2
Name
integrin beta 3b
Symbol
itgb3b Nomenclature History
Previous Names
  • itgb3.1 (1)
  • integrin beta 3.1 (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable fibronectin binding activity and integrin binding activity. Predicted to contribute to fibrinogen binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within platelet aggregation. Part of integrin complex. Is expressed in brain; cardiovascular system; dental epithelium; digestive system; and pectoral fin fold. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from Ablooglu et al., 2007
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itgb3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bleeding disorder, platelet-type, 24, autosomal dominant 619271
Glanzmann thrombasthenia 2 619267
Purpura, posttransfusion
Thrombocytopenia, neonatal alloimmune
{Myocardial infarction, susceptibility to} 608446
Associated With itgb3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002369 Integrin beta subunit, VWA domain
Domain IPR012896 Integrin beta subunit, tail
Domain IPR013111 EGF-like domain, extracellular
Domain IPR014836 Integrin beta subunit, cytoplasmic domain
Domain IPR016201 PSI domain
Domain IPR033760 Integrin beta N-terminal
Domain IPR040622 Integrin beta, epidermal growth factor-like domain 1
Family IPR015812 Integrin beta subunit
Family IPR027068 Integrin beta-3 subunit
Homologous_superfamily IPR032695 Integrin domain superfamily
Homologous_superfamily IPR036349 Integrin beta tail domain superfamily
Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
Domain Details Per Protein
Protein Length EGF-like domain, extracellular Integrin beta-3 subunit Integrin beta, epidermal growth factor-like domain 1 Integrin beta N-terminal Integrin beta subunit Integrin beta subunit, cytoplasmic domain Integrin beta subunit, tail Integrin beta subunit, VWA domain Integrin beta tail domain superfamily Integrin domain superfamily PSI domain von Willebrand factor A-like domain superfamily
UniProtKB:F8W5W7 41
UniProtKB:B3DIP9 790
UniProtKB:Q3LTM5 790
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations