ZFIN ID: ZDB-GENE-071207-2
Gene Name: integrin beta 3b
Gene Symbol: itgb3b    Nomenclature History

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Previous Names: itgb3.1 (1), integrin beta 3.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to contribute to fibrinogen binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Localizes to integrin complex. Is expressed in brain; cardiovascular system; dental epithelium; digestive system; and pectoral fin fold. Human ortholog(s) of this gene implicated in several diseases, including autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; non-arteritic anterior ischemic optic neuropathy; and platelet-type bleeding disorder 16. Orthologous to human ITGB3 (integrin subunit beta 3).
Genome Resources: Alliance (1),  Gene:100001836 (1),  Ensembl(GRCz11):ENSDARG00000045070 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17932 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH itgb3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Glanzmann's thrombasthenia Alliance Glanzmann thrombasthenia 273800
    platelet-type bleeding disorder 16 Alliance Bleeding disorder, platelet-type, 16, autosomal dominant 187800
    Purpura, posttransfusion
    Thrombocytopenia, neonatal alloimmune
    {Myocardial infarction, susceptibility to} 608446
    DISEASE ASSOCIATED WITH itgb3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell adhesion (more)
    Cellular Component integrin complex (more)
    Molecular Function protein binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itgb3b-201 (1)    Ensembl 2957
    itgb3b-202 (1)    Ensembl 434
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itgb3b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(itgb3b:EGFP) itgb3b EGFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    itgb3b Contained in: [BAC] DKEY-287G12 (1) (order this)
    itgb3b Encodes: [cDNA] MGC:195222 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001082948 (1) 2777 nt
    Genomic GenBank:BX530026 (1) 190980 nt
    Select Tool
    Polypeptide UniProtKB:B3DIP9 (1) 790 aa
    Sequence Information (all 12)
    ORTHOLOGY for itgb3b ( Chr: 12 )
    CITATIONS (26)