Gene

itgb3b

ID

ZDB-GENE-071207-2

Name

integrin beta 3b

Symbol

itgb3b Nomenclature History

Previous Names

itgb3.1 (1)
integrin beta 3.1 (1)

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Localizes to integrin complex. Human ortholog(s) of this gene implicated in several diseases, including autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal failure; non-arteritic anterior ischemic optic neuropathy; and platelet-type bleeding disorder 16. Is expressed in brain; cardiovascular system; dental epithelium; digestive system; and pectoral fin fold. Orthologous to human ITGB3 (integrin subunit beta 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Ablooglu et al., 2007

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With itgb3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Bleeding disorder, platelet-type, 24, autosomal dominant	619271
		Glanzmann thrombasthenia 2	619267
		Purpura, posttransfusion
		Thrombocytopenia, neonatal alloimmune
		{Myocardial infarction, susceptibility to}	608446

Associated With itgb3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002369	Integrin beta subunit, VWA domain
Domain	IPR012896	Integrin beta subunit, tail
Domain	IPR013111	EGF-like domain, extracellular
Domain	IPR014836	Integrin beta subunit, cytoplasmic domain
Domain	IPR016201	PSI domain
Domain	IPR033760	Integrin beta N-terminal
Domain	IPR040622	Integrin beta, epidermal growth factor-like domain 1
Family	IPR015812	Integrin beta subunit
Homologous_superfamily	IPR032695	Integrin domain superfamily
Homologous_superfamily	IPR036349	Integrin beta tail domain superfamily
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily