ZFIN ID: ZDB-GENE-071205-7
Gene Name: ATG12 autophagy related 12 homolog (S. cerevisiae)
Gene Symbol: atg12    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have Atg8 ligase activity. Predicted to be involved in C-terminal protein lipidation; autophagosome assembly; and autophagy of mitochondrion. Predicted to localize to the Atg12-Atg5-Atg16 complex and phagophore assembly site membrane. Is expressed in brain; liver; and muscle. Orthologous to human ATG12 (autophagy related 12).
Genome Resources: Alliance (1),  Gene:570965 (1),  Ensembl(GRCz11):ENSDARG00000069545 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 5 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ecn3 Small Deletion Unknown Unknown CRISPR
la019561Tg Transgenic Insertion Unknown Unknown DNA
la019562Tg Transgenic Insertion Unknown Unknown DNA
sa31002 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42684 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-atg12 2
    PHENOTYPE
    Data: Fig. 4 from Lu et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH atg12 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH atg12 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process autophagosome assembly (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR007242 Ubiquitin-like protein Atg12
    Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atg12-201 (1)    Ensembl 584
    atg12-202 (1)    Ensembl 668
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atg12 No data available
    MARKER RELATIONSHIPS
    atg12 Contained in: [BAC] CH211-149K23 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001246200 (1)
    Genomic GenBank:CU459065 (1) 150935 nt
    Select Tool
    Polypeptide UniProtKB:F1Q9E0 (1) 120 aa
    Sequence Information (all 16)
    ORTHOLOGY for atg12 ( Chr: 16 )
    CITATIONS (33)