Gene

ghrb

ID
ZDB-GENE-071119-4
Name
growth hormone receptor b
Symbol
ghrb Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have cytokine binding activity; peptide hormone binding activity; and prolactin receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in several structures, including muscle; nervous system; notochord; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ghrb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial hypercholesterolemia Alliance {Hypercholesterolemia, familial, modifier of} 143890
Laron syndrome Alliance Laron dwarfism 262500
Growth hormone insensitivity, partial 604271
Increased responsiveness to growth hormone 604271
Associated With ghrb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003961 Fibronectin type III
Domain IPR015152 Growth hormone/erythropoietin receptor, ligand binding
Domain IPR025871 Growth hormone-binding protein
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Growth hormone-binding protein Growth hormone/erythropoietin receptor, ligand binding Immunoglobulin-like fold
UniProtKB:D0EUN9 115
UniProtKB:A8WH88 554
UniProtKB:D0EUN8 114
UniProtKB:B4YQA4 555
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations