Gene

irak1

ID

ZDB-GENE-071116-5

Name

interleukin-1 receptor-associated kinase 1

Symbol

irak1 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in interleukin-1-mediated signaling pathway; intracellular signal transduction; and positive regulation of NF-kappaB transcription factor activity. Predicted to localize to cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With irak1 Human Ortholog

No data available

Associated With irak1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000488	Death domain
Domain	IPR000719	Protein kinase domain
Family	IPR050885	Innate Immune Response and Plant Defense Kinases
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011029	Death-like domain superfamily

Domain Details Per Protein

Protein	Length	Death domain	Death-like domain superfamily	Innate Immune Response and Plant Defense Kinases	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A8N7TBU9 InterPro	478
UniProtKB:F6NJE2 InterPro	686

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	irak1-202 (1) Ensembl	Ensembl	876 nt	Select Tool
mRNA	irak1-201 (1) Ensembl	Ensembl	2,318 nt	Select Tool
mRNA	irak1-203 (1) Ensembl	Ensembl	2,007 nt	Select Tool ZFIN BLAST
mRNA	irak1-204 (1) Ensembl	Ensembl	2,013 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations