Gene
irak1
- ID
- ZDB-GENE-071116-5
- Name
- interleukin-1 receptor-associated kinase 1
- Symbol
- irak1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Predicted to be involved in interleukin-1-mediated signaling pathway; intracellular signal transduction; and positive regulation of NF-kappaB transcription factor activity. Predicted to localize to cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000488 | Death domain |
| Domain | IPR000719 | Protein kinase domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Death domain | Death-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7TBU9
|
478 | ||||||
|
UniProtKB:F6NJE2
|
686 |
Interactions and Pathways
No data available
Plasmids
No data available