Gene
irak1
- ID
- ZDB-GENE-071116-5
- Name
- interleukin-1 receptor-associated kinase 1
- Symbol
- irak1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in cell surface receptor signaling pathway; intracellular signal transduction; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within protein phosphorylation and signal transduction. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016454Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15573 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21195 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34296 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa41119 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000488 | Death domain |
| Domain | IPR000719 | Protein kinase domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Death domain | Death-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7TBU9 | InterPro | 478 | ||||||
| UniProtKB:F6NJE2 | InterPro | 686 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-202G4 | ||
| Contained in | BAC | DKEYP-77F7 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005166703 (1) | 3111 nt | ||
| Genomic | GenBank:CR385024 | 207510 nt | ||
| Polypeptide | UniProtKB:F6NJE2 (1) | 686 aa |
- Weng, P., Lan, M., Zhang, H., Fan, H., Wang, X., Ran, C., Yue, Z., Hu, J., Xu, A., Huang, S. (2024) Both IRAK3 and IRAK1 Activate the MyD88-TRAF6 Pathway in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 213(3):362-372
- Li, Y., Shah, R.B., Sarti, S., Belcher, A.L., Lee, B.J., Gorbatenko, A., Nemati, F., Yu, H., Stanley, Z., Rahman, M., Shao, Z., Silva, J.M., Zha, S., Sidi, S. (2023) A noncanonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling. Science signaling. 16:eadh3449eadh3449
- Liyanage, T.D., Nikapitiya, C., Lee, J., De Zoysa, M. (2020) Molecular insight into regulation of miRNA in the spleen of zebrafish (Danio rerio) upon pathogenic Streptococcus parauberis infection. Fish & shellfish immunology. 106:898-909
- Liu, P.H., Shah, R.B., Li, Y., Arora, A., Ung, P.M., Raman, R., Gorbatenko, A., Kozono, S., Zhou, X.Z., Brechin, V., Barbaro, J.M., Thompson, R., White, R.M., Aguirre-Ghiso, J.A., Heymach, J.V., Lu, K.P., Silva, J.M., Panageas, K.S., Schlessinger, A., Maki, R.G., Skinner, H.D., de Stanchina, E., Sidi, S. (2019) An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nature cell biology. 21(2):203-213
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Pietri, T., Roman, A.C., Guyon, N., Romano, S.A., Washbourne, P., Moens, C.B., de Polavieja, G.G., and Sumbre, G. (2013) The first mecp2-null zebrafish model shows altered motor behaviors. Frontiers in neural circuits. 7:118
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Stein, C., Caccamo, M., Laird, G., and Leptin, M. (2007) Conservation and divergence of gene families encoding components of innate immune response systems in the zebrafish. Genome biology. 8(11):R251
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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