ZFIN ID: ZDB-GENE-071116-4
Gene Name: tyrosine kinase 2
Gene Symbol: tyk2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to localize to cytoskeleton and membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TYK2 (tyrosine kinase 2).
Genome Resources: Alliance (1),  Gene:100536675 (1),  Ensembl(GRCz11):ENSDARG00000020326 (2)
GENE EXPRESSION
All Expression Data: Fig. 5 from Gao et al., 2018
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015241Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2092 Point Mutation Unknown Splice Site ENU
    sa5732 Point Mutation Unknown Splice Site ENU
    sa13280 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31356 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tyk2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Immunodeficiency 35 611521
    DISEASE ASSOCIATED WITH tyk2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Cellular Component cytoskeleton (more)
    Molecular Function ATP binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tyk2-201 (1)    Ensembl 4696
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tyk2 No data available
    MARKER RELATIONSHIPS
    tyk2 Contained in: [BAC] CH211-66E2
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_003198153 (1)
    Genomic GenBank:CR354432 (1) 193960 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QJ02 (1) 1189 aa
    Sequence Information (all 12)
    ORTHOLOGY for tyk2 ( Chr: 3 )
    CITATIONS (25)