ZFIN ID: ZDB-GENE-071009-1
Gene Name: proprotein convertase subtilisin/kexin type 1
Gene Symbol: pcsk1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase activity. Predicted to be involved in peptide hormone processing. Predicted to localize to extracellular space; membrane; and neuron projection. Is expressed in several structures, including digestive system; heart; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1).
Genome Resources: Alliance (1),  Gene:100005716 (1),  Ensembl(GRCz11):ENSDARG00000002600 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1558 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9109 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pcsk1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    proprotein convertase 1/3 deficiency Alliance Obesity with impaired prohormone processing 600955
    {Obesity, susceptibility to, BMIQ12} 612362
    DISEASE ASSOCIATED WITH pcsk1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular space (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pcsk1-202 (1)    Ensembl 2513
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pcsk1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(pcsk1:EGFP) pcsk1 EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    pcsk1 Contained in: [BAC] DKEY-6B12 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001137662 (1) 2268 nt
    Genomic GenBank:BX511081 (1) 210246 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B6VCA1 (1) 755 aa
    Sequence Information (all 11)
    ORTHOLOGY for pcsk1 ( Chr: 21 )
    CITATIONS (31)