ZFIN ID: ZDB-GENE-071009-1
Gene Name: proprotein convertase subtilisin/kexin type 1
Gene Symbol: pcsk1
Location: Chr: 21   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Blastula:Dome (4.33h-4.66h) to Adult (90d-730d, breeding adult)
  brain, eye, gill, gonad (all 15) expand
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: pcsk1sa1558/sa1558(Tupfel long fin)

Allele Type Mutagen Suppliers
sa1558 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Phenotype of Human Orthologue OMIM Phenotype ID
    Obesity with impaired prohormone processing 600955
    {Obesity, susceptibility to, BMIQ12} 612362
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular space (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000209 (1)
  • InterPro:IPR002884 (1)
  • InterPro:IPR008979 (1)
  • InterPro:IPR009020 (1)
  • InterPro:IPR015500 (1)
  • InterPro:IPR022005 (1)
  • InterPro:IPR022398 (1)
  • InterPro:IPR023827 (1)
  • InterPro:IPR023828 (1)
  • PROSITE:PS00136 (1)
  • PROSITE:PS00137 (1)
  • PROSITE:PS00138 (1)
  • Pfam:PF00082 (1)
  • Pfam:PF01483 (1)
  • Pfam:PF12177 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pcsk1-001 (1) 2513
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pcsk1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pcsk1 Contained in: [BAC] DKEY-6B12 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001137662 (1) 2268 bp
    Genomic GenBank:BX511081 (1) 210246 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B6VCA1 (1) 755 aa
    Sequence Clusters UniGene:89425 (1)
    Sequence Information (all 10)
    OTHER pcsk1 GENE PAGES
  • Gene:100005716 (1)
  • VEGA:OTTDARG00000026857 (1)
  • Ensembl(Zv9):ENSDARG00000002600 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish pcsk1 21  
    Human PCSK1 5 (5q15-q21)
  • OMIM:162150
  • Gene:5122
  • Mouse Pcsk1 13 ( 40.63 cM)
  • MGI:97511
  • Gene:18548
  • Orthology Details
    CITATIONS (16)