ZFIN ID: ZDB-GENE-071009-1
Gene Name: proprotein convertase subtilisin/kexin type 1
Gene Symbol: pcsk1

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name:

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Blastula:Dome (4.33h-4.66h) to Adult (90d-730d, breeding adult)
  brain, eye, gill, gonad (all 15) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1558 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9109 Point Mutation Unknown Splice Site ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pcsk1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Obesity with impaired prohormone processing 600955
    {Obesity, susceptibility to, BMIQ12} 612362
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular space (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000209 (1)
  • InterPro:IPR002884 (1)
  • InterPro:IPR008979 (1)
  • InterPro:IPR009020 (1)
  • InterPro:IPR015500 (1)
  • InterPro:IPR022005 (1)
  • InterPro:IPR022398 (1)
  • InterPro:IPR023827 (1)
  • InterPro:IPR023828 (1)
  • InterPro:IPR032815 (1)
  • PROSITE:PS00136 (1)
  • PROSITE:PS00137 (1)
  • PROSITE:PS00138 (1)
  • Pfam:PF00082 (1)
  • Pfam:PF01483 (1)
  • Pfam:PF12177 (1)
  • Pfam:PF16470 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pcsk1-001 (1) 2513
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pcsk1
    Tg(pcsk1:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pcsk1Contained in: [BAC] DKEY-6B12 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001137662 (1) 2268bp
    Genomic GenBank:BX511081 (1) 210246bp Blast at MegaBLAST
    Polypeptide UniProtKB:B6VCA1 (1) 755aa
    Sequence Clusters UniGene:89425 (1)
    Sequence Information (all 11)
    OTHER pcsk1 GENE PAGES
  • Gene:100005716 (1)
  • VEGA:OTTDARG00000026857 (1)
  • Ensembl(GRCz10):ENSDARG00000002600 (1)
  • ORTHOLOGY for pcsk1 (Chr: 21)
    Species Symbol Chromosome Accession # Evidence
    Human PCSK1 5
  • Gene:5122
  • OMIM:162150
  • HGNC:8743
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Mouse Pcsk1 13
  • MGI:97511
  • Gene:18548
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (19)