Gene

pcsk1

ID
ZDB-GENE-071009-1
Name
proprotein convertase subtilisin/kexin type 1
Symbol
pcsk1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Predicted to be involved in peptide hormone processing. Predicted to localize to extracellular space; membrane; and neuron projection. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Is expressed in several structures, including digestive system; heart; integument; nervous system; and pleuroperitoneal region. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pcsk1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
proprotein convertase 1/3 deficiency Alliance Obesity with impaired prohormone processing 600955
{Obesity, susceptibility to, BMIQ12} 612362
Associated With pcsk1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR022398 Peptidase S8, subtilisin, His-active site
Active_site IPR023827 Peptidase S8, subtilisin, Asp-active site
Active_site IPR023828 Peptidase S8, subtilisin, Ser-active site
Domain IPR000209 Peptidase S8/S53 domain
Domain IPR002884 P domain
Domain IPR022005 Prohormone convertase enzyme
Domain IPR032815 Peptidase S8, pro-domain
Domain IPR034182 Kexin/furin catalytic domain
Family IPR015500 Peptidase S8, subtilisin-related
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR036852 Peptidase S8/S53 domain superfamily
Homologous_superfamily IPR038466 Peptidase S8, pro-domain superfamily
Domain Details Per Protein
Protein Length Galactose-binding-like domain superfamily Kexin/furin catalytic domain P domain Peptidase S8, pro-domain Peptidase S8, pro-domain superfamily Peptidase S8/S53 domain Peptidase S8/S53 domain superfamily Peptidase S8, subtilisin, Asp-active site Peptidase S8, subtilisin, His-active site Peptidase S8, subtilisin-related Peptidase S8, subtilisin, Ser-active site Prohormone convertase enzyme
UniProtKB:B6VCA1 755
UniProtKB:E9QIE6 754
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations