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Gene

fars2

ID
ZDB-GENE-070928-38
Name
phenylalanyl-tRNA synthetase 2, mitochondrial
Symbol
fars2 Nomenclature History
Previous Names
  • zgc:173439
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation and translation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fars2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined oxidative phosphorylation deficiency 14 Alliance Combined oxidative phosphorylation deficiency 14 614946
hereditary spastic paraplegia 77 Alliance Spastic paraplegia 77, autosomal recessive 617046
Associated With fars2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002319 Phenylalanyl-tRNA synthetase
Domain IPR005121 Ferrodoxin-fold anticodon-binding domain
Domain IPR006195 Aminoacyl-tRNA synthetase, class II
Family IPR004530 Phenylalanyl-tRNA synthetase, class IIc, mitochondrial
Homologous_superfamily IPR036690 Ferrodoxin-fold anticodon-binding domain superfamily
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class II Ferrodoxin-fold anticodon-binding domain Ferrodoxin-fold anticodon-binding domain superfamily Phenylalanyl-tRNA synthetase Phenylalanyl-tRNA synthetase, class IIc, mitochondrial
UniProtKB:A2RV45 465
UniProtKB:E7FBG2 449
UniProtKB:A8E4Z0 449
UniProtKB:A5PLE4 464
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations