ZFIN ID: ZDB-GENE-070925-2
Gene Name: tight junction protein 2a (zona occludens 2)
Gene Symbol: tjp2a    Nomenclature History

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Previous Names: tjp2.1 (1), wu:fb10a11, zo-2.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to localize to the bicellular tight junction. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 51; disease of metabolism; and progressive familial intrahepatic cholestasis 4. Is expressed in several structures, including digestive system; epidermis; nervous system; pronephros; and vasculature. Orthologous to human TJP2 (tight junction protein 2).
Genome Resources: Alliance (1),  Gene:565446 (1),  Ensembl(GRCz11):ENSDARG00000063309 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1367 Indel Unknown Unknown
la011800Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13709 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tjp2a
    3
    CRISPR2-tjp2a
    2
    CRISPR3-tjp2a
    1
    CRISPR4-tjp2a
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tjp2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    progressive familial intrahepatic cholestasis 4 Alliance Cholestasis, progressive familial intrahepatic 4 615878
    Hypercholanemia, familial 607748
    DISEASE ASSOCIATED WITH tjp2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component bicellular tight junction (more)
    GO Terms (all 1)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001452 SH3 domain
    Domain IPR001478 PDZ domain
    Family IPR005417 Tight junction protein ZO
    Family IPR005419 Tight junction protein ZO-2
    Domain IPR008144 Guanylate kinase-like domain
    Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR036028 SH3-like domain superfamily
    Homologous_superfamily IPR036034 PDZ superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tjp2a-202 (1)    Ensembl 4797
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tjp2a No data available
    MARKER RELATIONSHIPS
    tjp2a Contained in: [BAC] CH211-155E13, DKEY-3H23 (1) (order this)
    tjp2a Encodes: [EST] fb10a11
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001201571 (1) 4836 bp
    Genomic GenBank:BX629350 (1) 185084 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QB05 (1) 1225 aa
    Sequence Information (all 19)
    ORTHOLOGY for tjp2a ( Chr: 10 )
    CITATIONS (31)