Gene

egf

ID
ZDB-GENE-070922-1
Name
epidermal growth factor
Symbol
egf Nomenclature History
Previous Names
  • sb:eu639
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in blood circulation and cartilage development. Predicted to localize to plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); lung cancer (multiple); malignant glioma (multiple); and primary hypomagnesemia (multiple). Is expressed in several structures, including central nervous system; notochord; opercular flap; pleuroperitoneal region; and scale. Orthologous to human EGF (epidermal growth factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Pruvot et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With egf Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
renal hypomagnesemia 4 Alliance ?Hypomagnesemia 4, renal 611718
Associated With egf Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Family IPR016317 Pro-epidermal growth factor
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR000033 LDLR class B repeat
Domain Details Per Protein
Protein Length EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily LDLR class B repeat Pro-epidermal growth factor Six-bladed beta-propeller, TolB-like
UniProtKB:A0A140LGI0 1176
UniProtKB:B3DH82 1113
UniProtKB:F1QKU8 1114
UniProtKB:Q6VQA2 1114
UniProtKB:F1QGQ2 1113
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations