ZFIN ID: ZDB-GENE-070922-1
Gene Name: epidermal growth factor
Gene Symbol: egf    Nomenclature History

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Previous Name: sb:eu639

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in blood circulation and cartilage development. Predicted to localize to plasma membrane and receptor complex. Is expressed in several structures, including central nervous system; notochord; opercular flap; pleuroperitoneal region; and scale. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); lung cancer (multiple); malignant glioma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).
Genome Resources: Alliance (1),  Gene:403045 (1),  Ensembl(GRCz11):ENSDARG00000052739 (1)
GENE EXPRESSION
All Expression Data: 16 figures from 9 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2005 [eu639]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
DISEASE ASSOCIATED WITH egf HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
renal hypomagnesemia 4 Alliance Hypomagnesemia 4, renal 611718
DISEASE ASSOCIATED WITH egf VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process blood circulation (more)
Cellular Component integral component of membrane (more)
Molecular Function calcium ion binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA egf-201 (1)    Ensembl 3654
egf-203 (1)    Ensembl 3691
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM egf No data available
MARKER RELATIONSHIPS
egf Contained in: [BAC] DKEY-286H17 (1) (order this)
egf Encodes: [EST] eu639 (1)
[cDNA] MGC:194071 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_205731 (1) 3662 nt
Genomic GenBank:BX510944 (1) 131659 nt
Select Tool
Polypeptide UniProtKB:A0A140LGI0 (1) 1176 aa
Sequence Information (all 28)
ORTHOLOGY for egf ( Chr: 14 )
CITATIONS (50)