ZFIN ID: ZDB-GENE-070920-1
Gene Name: sodium channel, voltage-gated, type II, beta
Gene Symbol: scn2b    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have sodium channel regulator activity. Predicted to be involved in ion transport. Predicted to localize to the voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Is expressed in brain; eye; gill; heart; and liver. Orthologous to human SCN2B (sodium voltage-gated channel beta subunit 2).
Genome Resources: Alliance (1),  Gene:777666 (1),  Ensembl(GRCz11):ENSDARG00000101713 (1)
GENE EXPRESSION
All Expression Data: Fig. 5 from Chopra et al., 2007
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32016 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39036 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH scn2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial atrial fibrillation Alliance Atrial fibrillation, familial, 14 615378
    DISEASE ASSOCIATED WITH scn2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function sodium channel regulator activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000920 Myelin P0 protein-related
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Domain IPR013106 Immunoglobulin V-set domain
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Family IPR029873 Sodium channel subunit beta-2
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript scn2b-202 (1)    Ensembl 2448
    mRNA scn2b-203 (1)    Ensembl 918
    ncRNA scn2b-004 (1)    Ensembl 820
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM scn2b No data available
    MARKER RELATIONSHIPS
    scn2b Contained in: [BAC] CH211-184G13
    scn2b Encodes: [cDNA] MGC:194403 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077629 (1) 2449 bp
    Genomic GenBank:CU019627 (1) 39615 bp
    Select Tool
    Polypeptide UniProtKB:Q06W28 (1) 230 aa
    Sequence Information (all 21)
    ORTHOLOGY for scn2b ( Chr: 15 )
    CITATIONS (19)