ZFIN ID: ZDB-GENE-070912-70
Gene Name: transmembrane serine protease 3a
Gene Symbol: tmprss3a    Nomenclature History

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Previous Names: si:ch211-140m22.3, si:dkey-281i8.4 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have scavenger receptor activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 8 and sensorineural hearing loss. Orthologous to human TMPRSS3 (transmembrane serine protease 3).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000053315 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-tmprss3a
2
CRISPR2-tmprss3a
1
CRISPR3-tmprss3a
2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH tmprss3a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 8 Alliance Deafness, autosomal recessive 8/10 601072
DISEASE ASSOCIATED WITH tmprss3a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process proteolysis (more)
Cellular Component integral component of membrane (more)
Molecular Function hydrolase activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001190 SRCR domain
Domain IPR001254 Serine proteases, trypsin domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Domain IPR017448 SRCR-like domain
Active_site IPR018114 Serine proteases, trypsin family, histidine active site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036772 SRCR-like domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tmprss3a-202 (1)    Ensembl 1684
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tmprss3a No data available
MARKER RELATIONSHIPS
tmprss3a Contained in: [BAC] CH211-140M22 (1), DKEY-281I8 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
Genomic GenBank:BX294175 (1) 165355 bp
Select Tool
Polypeptide UniProtKB:F1QHZ9 (1) 543 aa
Sequence Information (all 4)
ORTHOLOGY for tmprss3a ( Chr: 9 )
CITATIONS (17)