Gene

nfatc4

ID
ZDB-GENE-070912-659
Name
nuclear factor of activated T cells 4
Symbol
nfatc4 Nomenclature History
Previous Names
  • si:dkeyp-66d1.4 (1)
  • si:dkeyp-66d1.5
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription factor binding activity. Predicted to be involved in calcineurin-NFAT signaling cascade; cytokine production; and regulation of transcription by RNA polymerase II. Predicted to localize to transcription regulator complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NFATC4 (nuclear factor of activated T cells 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Pistocchi et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nfatc4 Human Ortholog
No data available
Associated With nfatc4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002909 IPT domain
Domain IPR011539 Rel homology domain (RHD), DNA-binding domain
Domain IPR032397 Rel homology dimerisation domain
Family IPR008366 Nuclear factor of activated T cells (NFAT)
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin E-set Immunoglobulin-like fold IPT domain Nuclear factor of activated T cells (NFAT) p53-like transcription factor, DNA-binding Rel homology dimerisation domain Rel homology domain (RHD), DNA-binding domain Rel homology domain (RHD), DNA-binding domain superfamily
UniProtKB:X1WDL8 230
UniProtKB:E7F059 865
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations