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General Information
ZIRC
ZFIN ID: ZDB-GENE-070912-60
Gene Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Gene Symbol: serpine1
Sequence Ontology ID : SO:0001217

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Attributions

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Previous Names: PAI-1 (1), si:ch211-138a11.1

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(Including Attributions)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits serine-type endopeptidase inhibitor activity. Involved in negative regulation of plasminogen activation. Predicted to localize to the extracellular space. Human ortholog(s) of this gene  ...
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa508 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH serpine1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Plasminogen activator inhibitor-1 deficiency 613329
    {Transcription of plasminogen activator inhibitor, modulator of}
    DISEASE ASSOCIATED WITH serpine1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of plasminogen activation (more)
    Cellular Component extracellular space (more)
    Molecular Function serine-type endopeptidase inhibitor activity (more)
    GO Terms (all 4)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA serpine1-201 (1) 1789
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM serpine1 No data available
    MARKER RELATIONSHIPS
    serpine1 Contained in: [BAC] CH211-196F2 (1) (order this)
    serpine1 Encodes: [cDNA] MGC:174880 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001114559 (1) 1818 bp
    Genomic GenBank:BX470232 (1) 194721 bp
    Select Tool
    Polypeptide UniProtKB:F1QRB8 (1) 392 aa
    Sequence Clusters UniGene:119909 (1)
    Sequence Information (all 12)
    ORTHOLOGY for serpine1 ( Chr: 7 )
    CITATIONS (32)