Gene

serpine1

ID

ZDB-GENE-070912-60

Name

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Symbol

serpine1 Nomenclature History

Previous Names

PAI-1 (1)
si:ch211-138a11.1

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Exhibits serine-type endopeptidase inhibitor activity. Involved in negative regulation of plasminogen activation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 10 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Han et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With serpine1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Plasminogen activator inhibitor-1 deficiency	613329
		{Transcription of plasminogen activator inhibitor, modulator of}

Associated With serpine1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023795	Serpin, conserved site
Domain	IPR023796	Serpin domain
Family	IPR000215	Serpin family
Homologous_superfamily	IPR036186	Serpin superfamily
Homologous_superfamily	IPR042178	Serpin superfamily, domain 1
Homologous_superfamily	IPR042185	Serpin superfamily, domain 2