Gene

zeb2a

ID

ZDB-GENE-070912-553

Name

zinc finger E-box binding homeobox 2a

Symbol

zeb2a Nomenclature History

Previous Names

zeb2
sb:eu412
si:dkey-52o2.2
sip1a (1)
Smad-interacting protein-1a (1)
wu:fc92g08

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including chordate embryonic development; convergent extension; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including head; nervous system; neural plate; neuroectoderm; and tail bud. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu412 (26 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zeb2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Mowat-Wilson syndrome	Alliance	Mowat-Wilson syndrome	235730

Associated With zeb2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR008598	Drought induced 19 protein type, zinc-binding domain
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR051574	Zinc finger E-box-binding homeobox
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:B5DE38	InterPro	1175
UniProtKB:F1QY45	InterPro	1218
UniProtKB:A0A8M9Q4G0	InterPro	1095
UniProtKB:B0LVE9	InterPro	1201
UniProtKB:A0A8M2BFJ5	InterPro	1192

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	zeb2a-201 (1) Ensembl	Ensembl	4,058 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-202 (1) Ensembl	Ensembl	1,351 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-203 (1) Ensembl	Ensembl	448 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-204 (1) Ensembl	Ensembl	859 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-206 (1) Ensembl	Ensembl	4,250 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-207 (1) Ensembl	Ensembl	3,606 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-208 (1) Ensembl	Ensembl	5,237 nt	Select Tool ZFIN BLAST
ncRNA	zeb2a-004 (1) Ensembl	Ensembl	940 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations