Gene
agtr1a
- ID
- ZDB-GENE-070912-546
- Name
- angiotensin II receptor, type 1a
- Symbol
- agtr1a Nomenclature History
- Previous Names
-
- agtr1
- si:dkey-4m11.2
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Is predicted to enable angiotensin type I receptor activity. Involved in G protein-coupled receptor signaling pathway; inflammatory response; and positive regulation of cytosolic calcium ion concentration. Acts upstream of or within regulation of vasoconstriction and signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
essential hypertension | Alliance | {Hypertension, essential} | 145500 |
Renal tubular dysgenesis | 267430 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Angiotensin II receptor family | Angiotensin II receptor type 1 | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
---|---|---|---|---|---|
UniProtKB:B0V116
|
358 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
agtr1a-201
(1)
|
1077 nt |
Interactions and Pathways
No data available
Plasmids
No data available