ZFIN ID: ZDB-GENE-070912-546
Gene Name: angiotensin II receptor, type 1a
Gene Symbol: agtr1a    Nomenclature History

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Previous Names: agtr1, si:dkey-4m11.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have angiotensin type I receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; inflammatory response; and positive regulation of cytosolic calcium ion concentration. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); cerebrovascular disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1).
Genome Resources: Alliance (1),  Gene:794575 (1),  Ensembl(GRCz11):ENSDARG00000018616 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32924 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH agtr1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    essential hypertension Alliance {Hypertension, essential} 145500
    Renal tubular dysgenesis 267430
    DISEASE ASSOCIATED WITH agtr1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function angiotensin type II receptor activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA agtr1a-201 (1)    Ensembl 1077
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM agtr1a No data available
    MARKER RELATIONSHIPS
    agtr1a Contained in: [BAC] DKEY-4M11 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_017351685 (1)
    Genomic GenBank:CR788256 (1) 52648 nt
    Select Tool
    Polypeptide UniProtKB:B0V116 (1) 358 aa
    Sequence Information (all 6)
    ORTHOLOGY for agtr1a ( Chr: 2 )
    CITATIONS (16)