Gene
agtr1a
- ID
- ZDB-GENE-070912-546
- Name
- angiotensin II receptor, type 1a
- Symbol
- agtr1a Nomenclature History
- Previous Names
-
- agtr1
- si:dkey-4m11.2
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have angiotensin type I receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; inflammatory response; and positive regulation of cytosolic calcium ion concentration. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1).
- Genome Resources
- Note
- None
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | {Hypertension, essential} | 145500 |
| Renal tubular dysgenesis | 267430 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Angiotensin II receptor family | Angiotensin II receptor type 1 | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:B0V116
|
358 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
agtr1a-201
(1)
|
1077 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl