| ZFIN ID: ZDB-GENE-070912-546 |
| Gene Name: | angiotensin II receptor, type 1a | |||||||||||||
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| Gene Symbol: | agtr1a Nomenclature History |
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| Previous Names: | agtr1, si:dkey-4m11.2 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 2 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have angiotensin type I receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; inflammatory response; and positive regulation of cytosolic calcium ion concentration. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:794575 (1), Ensembl(GRCz11):ENSDARG00000018616 (1) | |||||||||||||
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa32924 | Point Mutation | Unknown | Premature Stop | ENU |
|
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | {Hypertension, essential} | 145500 |
| Renal tubular dysgenesis | 267430 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | G protein-coupled receptor signaling pathway (more) |
| Cellular Component | integral component of membrane (more) |
| Molecular Function | angiotensin type II receptor activity (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
agtr1a-201
(1)
|
1077 |
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|
| Browsers: NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM agtr1a
No data available
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:XM_017351685 (1) |
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| Genomic | GenBank:CR788256 (1) | 52648 nt | |
| Polypeptide | UniProtKB:B0V116 (1) | 358 aa |
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ORTHOLOGY for agtr1a (
Chr:
2
)
CITATIONS (16)