Gene

kif1ab

ID
ZDB-GENE-070912-480
Name
kinesin family member 1Ab
Symbol
kif1ab Nomenclature History
Previous Names
  • si:dkey-261l2.2
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Predicted to be involved in cytoskeleton-dependent intracellular transport; microtubule-based movement; and vesicle-mediated transport. Predicted to localize to axon; dendrite; and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in NESCAV syndrome; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (kinesin family member 1A).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kif1ab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary sensory neuropathy type 2C Alliance Neuropathy, hereditary sensory, type IIC 614213
hereditary spastic paraplegia 30 Alliance Spastic paraplegia 30, autosomal dominant 610357
hereditary spastic paraplegia 30 Alliance Spastic paraplegia 30, autosomal recessive 610357
NESCAV syndrome Alliance NESCAV syndrome 614255
Associated With kif1ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019821 Kinesin motor domain, conserved site
Domain IPR000253 Forkhead-associated (FHA) domain
Domain IPR001752 Kinesin motor domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR022140 Kinesin-like KIF1-type
Domain IPR022164 Kinesin-like
Domain IPR032405 Kinesin-associated
Family IPR027640 Kinesin-like protein
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length Forkhead-associated (FHA) domain Kinesin-associated Kinesin-like Kinesin-like KIF1-type Kinesin-like protein Kinesin motor domain Kinesin motor domain, conserved site Kinesin motor domain superfamily PH-like domain superfamily Pleckstrin homology domain P-loop containing nucleoside triphosphate hydrolase SMAD/FHA domain superfamily
UniProtKB:B0S7L9 1785
UniProtKB:F1QBI0 297
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations