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Gene

gad1a

ID
ZDB-GENE-070912-472
Name
glutamate decarboxylase 1a
Symbol
gad1a Nomenclature History
Previous Names
  • si:dkey-249g23.3
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable carboxy-lyase activity and pyridoxal phosphate binding activity. Predicted to act upstream of or within carboxylic acid metabolic process. Is expressed in brain. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; developmental and epileptic encephalopathy 89; schizophrenia; and spastic quadriplegia. Orthologous to human GAD1 (glutamate decarboxylase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Cocco et al., 2017
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gad1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 89 Alliance Developmental and epileptic encephalopathy 89 619124
Associated With gad1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021115 Pyridoxal-phosphate binding site
Family IPR002129 Pyridoxal phosphate-dependent decarboxylase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Pyridoxal-phosphate binding site Pyridoxal phosphate-dependent decarboxylase Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:E7FDZ2 595
UniProtKB:F6NX32 591
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations