ZFIN ID: ZDB-GENE-070912-472
Gene Name: glutamate decarboxylase 1a
Gene Symbol: gad1a    Nomenclature History

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Previous Name: si:dkey-249g23.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have carboxy-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in carboxylic acid metabolic process. Is expressed in brain. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; schizophrenia; and spastic quadriplegia. Orthologous to human GAD1 (glutamate decarboxylase 1).
Genome Resources: Alliance (1),  Gene:100329827 (1),  Ensembl(GRCz11):ENSDARG00000093411 (1)
GENE EXPRESSION
All Expression Data: text only from Cocco et al., 2017
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029592Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10333 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21424 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gad1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spastic quadriplegia Alliance ?Cerebral palsy, spastic quadriplegic, 1 603513
    DISEASE ASSOCIATED WITH gad1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process carboxylic acid metabolic process (more)
    Molecular Function carboxy-lyase activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gad1a-202 (1)    Ensembl 1776
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gad1a No data available
    MARKER RELATIONSHIPS
    gad1a Contained in: [BAC] DKEY-88M1 (1) (order this), DKEY-249G23 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002663304 (1)
    Genomic GenBank:CR394567 (1) 189488 nt
    Select Tool
    Polypeptide UniProtKB:E7FDZ2 (1) 595 aa
    Sequence Information (all 14)
    ORTHOLOGY for gad1a ( Chr: 9 )
    CITATIONS (19)