ZFIN ID: ZDB-GENE-070912-442
Gene Name: protein kinase, AMP-activated, gamma 2 non-catalytic subunit b
Gene Symbol: prkag2b    Nomenclature History

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Previous Names: prkag2, si:ch211-230l11.1, si:dkey-217f4.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to contribute to AMP-activated protein kinase activity. Predicted to be involved in cellular response to glucose starvation; protein phosphorylation; and regulation of catalytic activity. Predicted to localize to cytoplasm; nucleotide-activated protein kinase complex; and nucleus. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2).
Genome Resources: Alliance (1),  Gene:568316 (1),  Ensembl(GRCz11):ENSDARG00000001933 (2)
GENE EXPRESSION
All Expression Data: Fig. 3 from Meireles et al., 2018
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014818Tg Transgenic Insertion Unknown Unknown DNA
la014819Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la023446Tg Transgenic Insertion Unknown Unknown DNA
    sa44523 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-prkag2b
    1
    MO1-prkag2b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH prkag2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypertrophic cardiomyopathy 6 Alliance Cardiomyopathy, hypertrophic 6 600858
    lethal congenital glycogen storage disease of heart Alliance Glycogen storage disease of heart, lethal congenital 261740
    Wolff-Parkinson-White syndrome Alliance Wolff-Parkinson-White syndrome 194200
    DISEASE ASSOCIATED WITH prkag2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of protein serine/threonine kinase activity (more)
    Cellular Component cytoplasm (more)
    Molecular Function adenyl ribonucleotide binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prkag2b-201 (1)    Ensembl 2139
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prkag2b No data available
    MARKER RELATIONSHIPS
    prkag2b Contained in: [BAC] CH211-230L11 (1), DKEY-217F4 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_691638 (1) 2286 nt
    Genomic GenBank:BX511000 (1) 191671 nt
    Select Tool
    Polypeptide UniProtKB:F1QRT4 (1) 533 aa
    Sequence Information (all 14)
    ORTHOLOGY for prkag2b ( Chr: 2 )
    CITATIONS (21)