Gene
map3k20a
- ID
- ZDB-GENE-070912-386
- Name
- mitogen-activated protein kinase kinase kinase 20a
- Symbol
- map3k20a Nomenclature History
- Previous Names
-
- zak
- si:dkey-15i8.3
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Snieckute et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Snieckute et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| centronuclear myopathy 6 with fiber-type disproportion | Alliance | Centronuclear myopathy 6 with fiber-type disproportion | 617760 |
| Split-foot malformation with mesoaxial polydactyly | 616890 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Family | IPR051681 | Serine/Threonine Kinases and Pseudokinases |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase domain | Protein kinase-like domain superfamily | Serine/Threonine Kinases and Pseudokinases | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0S4Y7 | InterPro | 789 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance