Gene

irf4a

ID
ZDB-GENE-070912-330
Name
interferon regulatory factor 4a
Symbol
irf4a Nomenclature History
Previous Names
  • irf4
  • si:ch73-170d1.2 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within lymphoid lineage cell migration into thymus; lymphoid progenitor cell differentiation; and negative regulation of myeloid cell differentiation. Located in chromatin and nucleus. Is expressed in several structures, including hematopoietic multipotent progenitor cell; hematopoietic system; liver; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; anaplastic large cell lymphoma; chronic lymphocytic leukemia; multiple myeloma; and peripheral T-cell lymphoma. Orthologous to human IRF4 (interferon regulatory factor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Wang et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irf4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
[Skin/hair/eye pigmentation, variation in, 8] 611724
Associated With irf4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019817 Interferon regulatory factor, conserved site
Domain IPR001346 Interferon regulatory factor DNA-binding domain
Domain IPR019471 Interferon regulatory factor-3
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Interferon regulatory factor-3 Interferon regulatory factor, conserved site Interferon regulatory factor DNA-binding domain SMAD/FHA domain superfamily SMAD-like domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:A8B8L1 460
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations