ZFIN ID: ZDB-GENE-070912-274
Gene Name: collagen, type VIII, alpha 1a
Gene Symbol: col8a1a    Nomenclature History

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Previous Names: Col8A1.1 (1), col8a1 (1), lev, gul (1), gulliver (1), leviathan, si:ch211-283e2.6 (1), wu:fb18b08 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have extracellular matrix structural constituent. Involved in head development and notochord formation. Predicted to localize to the extracellular matrix and extracellular space. Is expressed in several structures, including epidermis; hypochord; notochord; prechordal plate; and splanchnocranium. Orthologous to human COL8A1 (collagen type VIII alpha 1 chain).
Genome Resources: Alliance (1),  Gene:557795 (1),  Ensembl(GRCz11):ENSDARG00000077403 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m208 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m531 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • pd1100 Point Mutation Unknown Premature Stop
    sa6114 Point Mutation Unknown Splice Site ENU
    sa13665 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34670 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vu41 Point Mutation Unknown Premature Stop
    vu105 Point Mutation Unknown Missense
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-col8a1a N/A 2
    MO2-col8a1a N/A 2
    DISEASE ASSOCIATED WITH col8a1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH col8a1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process head development (more)
    Cellular Component collagen trimer (more)
    Molecular Function extracellular matrix structural constituent (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001073 C1q domain
    Repeat IPR008160 Collagen triple helix repeat
    Homologous_superfamily IPR008983 Tumour necrosis factor-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA col8a1a-201 (1)    Ensembl 2256
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM col8a1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(col8a1a:GFP-CAAX) col8a1a CAAXGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    col8a1a Contained in: [BAC] CH211-283E2 (1)
    col8a1a Encodes: [EST] fb18b08 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001142374 (1) 2176 bp
    Genomic GenBank:BX322575 (1) 149874 bp
    Select Tool
    Polypeptide UniProtKB:B0S5W0 (1) 711 aa
    Sequence Information (all 10)
    ORTHOLOGY for col8a1a ( Chr: 9 )
    CITATIONS (36)