Gene

c8b

ID
ZDB-GENE-070912-163
Name
complement component 8, beta polypeptide
Symbol
c8b Nomenclature History
Previous Names
  • si:ch211-188c16.3
  • wu:fi18d09
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to be involved in complement activation. Predicted to localize to membrane attack complex. Is expressed in liver. Human ortholog(s) of this gene implicated in type II complement component 8 deficiency. Orthologous to human C8B (complement C8 beta chain).
Genome Resources
Note
None
Expression
All Expression Data
Fig. s2 from Takada et al., 2017
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c8b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type II complement component 8 deficiency Alliance C8 deficiency, type II 613789
Associated With c8b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020863 Membrane attack complex component/perforin domain, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR020864 Membrane attack complex component/perforin (MACPF) domain
Family IPR001862 Membrane attack complex component/perforin/complement C9
Family IPR037566 Complement component C8 beta chain
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Complement component C8 beta chain LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Membrane attack complex component/perforin/complement C9 Membrane attack complex component/perforin domain, conserved site Membrane attack complex component/perforin (MACPF) domain Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A2R8QGK2 166
UniProtKB:A8HAJ8 562
UniProtKB:A0A0B5JSF5 262
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations