ZFIN ID: ZDB-GENE-070912-163
Gene Name: complement component 8, beta polypeptide
Gene Symbol: c8b    Nomenclature History

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Previous Names: si:ch211-188c16.3, wu:fi18d09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to be involved in complement activation. Predicted to localize to the membrane attack complex. Human ortholog(s) of this gene implicated in type II complement component 8 deficiency. Is expressed in liver. Orthologous to human C8B (complement C8 beta chain).
Genome Resources: Alliance (1),  Gene:793127 (1),  Ensembl(GRCz11):ENSDARG00000039517 (2)
GENE EXPRESSION
All Expression Data: Fig. s2 from Takada et al., 2017
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Day 4 (96.0h-120.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH c8b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type II complement component 8 deficiency Alliance C8 deficiency, type II 613789
DISEASE ASSOCIATED WITH c8b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process complement activation (more)
Cellular Component membrane attack complex (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Family IPR001862 Membrane attack complex component/perforin/complement C9
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Conserved_site IPR020863 Membrane attack complex component/perforin domain, conserved site
Domain IPR020864 Membrane attack complex component/perforin (MACPF) domain
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Family IPR037566 Complement component C8 beta chain
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA c8b-201 (1)    Ensembl 2271
ncRNA c8b-002 (1) 590
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM c8b No data available
MARKER RELATIONSHIPS
c8b Contained in: [BAC] CH211-188C16 (1)
c8b Encodes: [EST] fi18d09
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001256723 (1) 1736 bp
Genomic GenBank:CR848026 (1) 139240 bp
Select Tool
Polypeptide UniProtKB:A8HAJ8 (1) 562 aa
Sequence Information (all 12)
ORTHOLOGY for c8b ( Chr: 2 )
CITATIONS (16)