Gene

c8b

ID
ZDB-GENE-070912-163
Name
complement component 8, beta polypeptide
Symbol
c8b Nomenclature History
Previous Names
  • si:ch211-188c16.3
  • wu:fi18d09
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to be involved in complement activation, classical pathway; cytolysis; and innate immune response. Predicted to localize to extracellular region and membrane attack complex. Is expressed in liver. Human ortholog(s) of this gene implicated in type II complement component 8 deficiency. Orthologous to human C8B (complement C8 beta chain).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Takada et al., 2017
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c8b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type II complement component 8 deficiency Alliance C8 deficiency, type II 613789
Associated With c8b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020863 Membrane attack complex component/perforin domain, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR020864 Membrane attack complex component/perforin (MACPF) domain
Family IPR001862 Membrane attack complex component/perforin/complement C9
Family IPR037566 Complement component C8 beta chain
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Complement component C8 beta chain LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Membrane attack complex component/perforin/complement C9 Membrane attack complex component/perforin domain, conserved site Membrane attack complex component/perforin (MACPF) domain Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A0B5JSF5 262
UniProtKB:A0A2R8QGK2 166
UniProtKB:A8HAJ8 562
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations