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ZIRC
ZFIN ID: ZDB-GENE-070912-124
Gene Name: zinc finger E-box binding homeobox 1a
Gene Symbol: zeb1a    Nomenclature History

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Previous Name: si:ch211-159p3.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have DNA binding activity and metal ion binding activity. Involved in regulation of cell-cell adhesion involved in gastrulation and smooth muscle tissue development. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Is expressed in hypoblast and neural plate. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1).
Genome Resources: Alliance (1),  Gene:100004929 (1),  Ensembl(GRCz11):ENSDARG00000016788 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028823Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028824Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa838 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15743 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-zeb1a N/A 1
    MO2-zeb1a N/A 1
    MO3-zeb1a N/A 1
    MO4-zeb1a N/A 1
    MO5-zeb1a N/A 1
    DISEASE ASSOCIATED WITH zeb1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Fuchs' endothelial dystrophy Alliance Corneal dystrophy, Fuchs endothelial, 6 613270
    posterior polymorphous corneal dystrophy 3 Alliance Corneal dystrophy, posterior polymorphous, 3 609141
    DISEASE ASSOCIATED WITH zeb1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of cell-cell adhesion involved in gastrulation (more)
    Molecular Function DNA binding (more)
    GO Terms (all 6)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA zeb1a-203 (1)    Ensembl 761
    zeb1a-204 (1)    Ensembl 3650
    ncRNA zeb1a-002 (1)    Ensembl 568
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM zeb1a No data available
    MARKER RELATIONSHIPS
    zeb1a Contained in: [BAC] CH211-159P3 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001344071 (1)
    Genomic GenBank:CR457482 (1) 158288 bp
    Select Tool
    Polypeptide UniProtKB:F1QMZ5 (1) 1190 aa
    Sequence Clusters UniGene:86951 (1)
    Sequence Information (all 19)
    ORTHOLOGY for zeb1a ( Chr: 2 )
    CITATIONS (20)