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Gene

zeb1a

ID
ZDB-GENE-070912-124
Name
zinc finger E-box binding homeobox 1a
Symbol
zeb1a Nomenclature History
Previous Names
  • si:ch211-159p3.1
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including regulation of cell-cell adhesion involved in gastrulation; regulation of gastrulation; and smooth muscle tissue development. Is expressed in hypoblast and neural plate. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Gays et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zeb1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fuchs' endothelial dystrophy Alliance Corneal dystrophy, Fuchs endothelial, 6 613270
posterior polymorphous corneal dystrophy 3 Alliance Corneal dystrophy, posterior polymorphous, 3 609141
Associated With zeb1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Domain IPR008598 Drought induced 19 protein type, zinc-binding domain
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Drought induced 19 protein type, zinc-binding domain Homeobox domain Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:F1QBD3 1176
UniProtKB:F1QMZ5 1190
UniProtKB:A0A2R8QV74 1174
UniProtKB:F1QL88 206
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations