ZFIN ID: ZDB-GENE-070824-4
Gene Name: nuclear receptor subfamily 4, group A, member 3
Gene Symbol: nr4a3    Nomenclature History

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Previous Name: NOR1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II proximal promoter sequence-specific DNA binding activity and glucocorticoid receptor binding activity. Involved in neutrophil homeostasis. Predicted to localize to the nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in extraskeletal myxoid chondrosarcoma. Is expressed in basal plate midbrain region; brain; neurons; and spinal cord. Orthologous to human NR4A3 (nuclear receptor subfamily 4 group A member 3).
Genome Resources: Alliance (1),  Gene:548604 (1),  Ensembl(GRCz11):ENSDARG00000055854 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2842 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nr4a3 N/A 1
    PHENOTYPE
    Data: Fig. 7 from Prince et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH nr4a3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    extraskeletal myxoid chondrosarcoma Alliance Chondrosarcoma, extraskeletal myxoid 612237
    DISEASE ASSOCIATED WITH nr4a3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neutrophil homeostasis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
    Domain IPR001628 Zinc finger, nuclear hormone receptor-type
    Family IPR001723 Nuclear hormone receptor
    Family IPR003070 Orphan nuclear receptor
    Family IPR003073 Orphan nuclear receptor, NURR type
    Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
    Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nr4a3-201 (1)    Ensembl 3244
    nr4a3-202 (1)    Ensembl 748
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nr4a3 No data available
    MARKER RELATIONSHIPS
    nr4a3 Contained in: [BAC] CH211-192F15 (1)
    nr4a3 Encodes: [EST] dq017611 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001172629 (1) 2119 nt
    Genomic GenBank:CR524821 (1) 152728 nt
    Select Tool
    Polypeptide UniProtKB:F1R8N1 (1) 594 aa
    Sequence Information (all 17)
    ORTHOLOGY for nr4a3 ( Chr: 16 )
    CITATIONS (29)