ZFIN ID: ZDB-GENE-070821-3
Gene Name: cholinergic receptor, nicotinic, beta 2
Gene Symbol: chrnb2    Nomenclature History

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Previous Names: chrnb2, chrnb2b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to contribute to acetylcholine binding activity and acetylcholine receptor activity. Predicted to be involved in several processes, including chemical synaptic transmission; regulation of membrane potential; and response to nicotine. Predicted to localize to acetylcholine-gated channel complex; neuron projection; and synapse. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit).
Genome Resources: Alliance (1),  Gene:561906 (1),  Ensembl(GRCz11):ENSDARG00000017790 (2)
GENE EXPRESSION
All Expression Data: Table 3 from Parker et al., 2015
Wild-type Stages, Structures: Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17637 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH chrnb2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nocturnal frontal lobe epilepsy 3 Alliance Epilepsy, nocturnal frontal lobe, 3 605375
    DISEASE ASSOCIATED WITH chrnb2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transmembrane transport (more)
    Cellular Component cell junction (more)
    Molecular Function acetylcholine-gated cation-selective channel activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chrnb2b-202 (1)    Ensembl 1685
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chrnb2 No data available
    MARKER RELATIONSHIPS
    chrnb2 Contained in: [BAC] CH211-105C13
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005169754 (1) 4743 nt
    Genomic GenBank:BX950871 (1) 165048 nt
    Select Tool
    Polypeptide UniProtKB:E7F4S7 (1) 543 aa
    Sequence Information (all 9)
    ORTHOLOGY for chrnb2 ( Chr: 16 )
    CITATIONS (23)