ZFIN ID: ZDB-GENE-070820-10
Gene Name: ligase IV, DNA, ATP-dependent
Gene Symbol: lig4    Nomenclature History

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Previous Name: zgc:165595 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to localize to the DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; multiple myeloma; pancreatic cancer; and prostate cancer. Orthologous to human LIG4 (DNA ligase 4).
Genome Resources: Alliance (1),  Gene:569525 (1),  Ensembl(GRCz11):ENSDARG00000060620 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh302 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • fh303 Point Mutation Unknown Unknown ENU
    lig4_unrecovered Point Mutation Unknown Unknown ENU
    sa13669 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32694 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38268 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko558a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko558b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lig4
    1
    MO1-lig4 N/A 4
    DISEASE ASSOCIATED WITH lig4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    DNA ligase IV deficiency Alliance LIG4 syndrome 606593
    multiple myeloma Alliance {Multiple myeloma, resistance to} 254500
    DISEASE ASSOCIATED WITH lig4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process double-strand break repair via nonhomologous end joining (more)
    Cellular Component DNA-dependent protein kinase-DNA ligase 4 complex (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000977 DNA ligase, ATP-dependent
    Domain IPR001357 BRCT domain
    Domain IPR012308 DNA ligase, ATP-dependent, N-terminal
    Domain IPR012309 DNA ligase, ATP-dependent, C-terminal
    Domain IPR012310 DNA ligase, ATP-dependent, central
    Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
    Conserved_site IPR016059 DNA ligase, ATP-dependent, conserved site
    Domain IPR021536 DNA ligase IV domain
    Family IPR029710 DNA ligase 4
    Homologous_superfamily IPR036420 BRCT domain superfamily
    Homologous_superfamily IPR036599 DNA ligase, ATP-dependent, N-terminal domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lig4-201 (1)    Ensembl 3262
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lig4 No data available
    MARKER RELATIONSHIPS
    lig4 Contained in: [BAC] CH211-198K9 (1)
    lig4 Encodes: [cDNA] MGC:165595 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001103123 (1) 3084 bp
    Genomic GenBank:BX908780 (1) 199679 bp
    Select Tool
    Polypeptide UniProtKB:A7E283 (1) 909 aa
    Sequence Information (all 11)
    ORTHOLOGY for lig4 ( Chr: 1 )
    CITATIONS (31)