Gene

lig4

ID
ZDB-GENE-070820-10
Name
ligase IV, DNA, ATP-dependent
Symbol
lig4 Nomenclature History
Previous Names
  • zgc:165595 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Involved in double-strand break repair via nonhomologous end joining. Predicted to localize to DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; malignant glioma; multiple myeloma; and prostate cancer. Orthologous to human LIG4 (DNA ligase 4).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Bian et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lig4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
DNA ligase IV deficiency Alliance LIG4 syndrome 606593
multiple myeloma Alliance {Multiple myeloma, resistance to} 254500
Associated With lig4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR016059 DNA ligase, ATP-dependent, conserved site
Domain IPR001357 BRCT domain
Domain IPR012308 DNA ligase, ATP-dependent, N-terminal
Domain IPR012309 DNA ligase, ATP-dependent, C-terminal
Domain IPR012310 DNA ligase, ATP-dependent, central
Domain IPR021536 DNA ligase IV domain
Domain IPR044125 DNA Ligase 4, adenylation domain
Family IPR000977 DNA ligase, ATP-dependent
Family IPR029710 DNA ligase 4
Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
Homologous_superfamily IPR036420 BRCT domain superfamily
Homologous_superfamily IPR036599 DNA ligase, ATP-dependent, N-terminal domain superfamily
Domain Details Per Protein
Protein Length BRCT domain BRCT domain superfamily DNA ligase 4 DNA Ligase 4, adenylation domain DNA ligase, ATP-dependent DNA ligase, ATP-dependent, central DNA ligase, ATP-dependent, conserved site DNA ligase, ATP-dependent, C-terminal DNA ligase, ATP-dependent, N-terminal DNA ligase, ATP-dependent, N-terminal domain superfamily DNA ligase IV domain Nucleic acid-binding, OB-fold
UniProtKB:A7E283 909
UniProtKB:F1Q9E8 909
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations