Gene

adamts2a

ID

ZDB-GENE-070816-3

Name

ADAM metallopeptidase with thrombospondin type 1 motif, 2a

Symbol

adamts2a Nomenclature History

Previous Names

ADAMTS2/3 (1)
adamts22
adamts2

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Orthologous to human ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Yao et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adamts2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Ehlers-Danlos syndrome dermatosparaxis type	Alliance	Ehlers-Danlos syndrome, dermatosparaxis type	225410

Associated With adamts2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR002870	Peptidase M12B, propeptide
Domain	IPR010294	ADAMTS/ADAMTS-like, Spacer 1
Domain	IPR010909	PLAC
Domain	IPR041645	ADAMTS, cysteine-rich domain 2
Domain	IPR045371	ADAMTS/ADAMTS-like, cysteine-rich domain 3
Family	IPR013273	ADAMTS/ADAMTS-like
Family	IPR050439	ADAMTS and ADAMTS-like
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat

Domain Details Per Protein

Protein	Length	ADAMTS/ADAMTS-like	ADAMTS/ADAMTS-like, cysteine-rich domain 3	ADAMTS/ADAMTS-like, Spacer 1	ADAMTS and ADAMTS-like	ADAMTS, cysteine-rich domain 2	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin	Peptidase M12B, propeptide	PLAC	Thrombospondin type-1 (TSP1) repeat	Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A8M9Q7A9 InterPro	159
UniProtKB:A0A0R4ISF7 InterPro	1295

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	adamts2-202 (1) Ensembl	Ensembl	3,772 nt	Select Tool
mRNA	adamts2-203 (1) Ensembl	Ensembl	7,967 nt	Select Tool ZFIN BLAST
ncRNA	adamts2-002 (1) Ensembl	Ensembl	465 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Huxley-Jones et al. (ZDB-PUB-070427-22) list ADAMTS2/3 as the ortholog of both human ADAMTS2 and ADAMTS3 based on amino acid sequence identity.

Citations