Gene

adamts2

ID
ZDB-GENE-070816-3
Name
ADAM metallopeptidase with thrombospondin type 1 motif, 2
Symbol
adamts2 Nomenclature History
Previous Names
  • ADAMTS2/3 (1)
  • adamts22
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome. Orthologous to human ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from Brunet et al., 2015
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adamts2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ehlers-Danlos syndrome dermatosparaxis type Alliance Ehlers-Danlos syndrome, dermatosparaxis type 225410
Associated With adamts2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR002870 Peptidase M12B, propeptide
Domain IPR010294 ADAM-TS Spacer 1
Domain IPR010909 PLAC
Domain IPR041645 ADAM cysteine-rich domain 2
Family IPR013273 ADAMTS/ADAMTS-like
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Domain Details Per Protein
Protein Length ADAM cysteine-rich domain 2 ADAMTS/ADAMTS-like ADAM-TS Spacer 1 Metallopeptidase, catalytic domain superfamily Peptidase M12B, ADAM/reprolysin Peptidase M12B, propeptide PLAC Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:F1R544 1257
UniProtKB:A0A0R4ISF7 1295
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Orthology Note
Huxley-Jones et al. (ZDB-PUB-070427-22) list ADAMTS2/3 as the ortholog of both human ADAMTS2 and ADAMTS3 based on amino acid sequence identity.
Citations