ZFIN ID: ZDB-GENE-070815-1
Gene Name: ADAM metallopeptidase with thrombospondin type 1 motif, 18
Gene Symbol: adamts18
Location: Chr: 7   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from Brunet et al., 2015
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, eye, gut, heart (all 13) expand
MUTANTS AND TARGETED KNOCKDOWNS

Allele Type Mutagen Suppliers
la016124Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la016125Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026069Tg Transgenic Insertion DNA
    la026070Tg Transgenic Insertion DNA
    sa12213 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa14714 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa21040 Point Mutation ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH adamts18 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Microcornea, myopic chorioretinal atrophy, and telecanthus 615458
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular matrix (more)
    Molecular Function metalloendopeptidase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000884 (1)
  • InterPro:IPR001590 (1)
  • InterPro:IPR002870 (1)
  • InterPro:IPR010294 (1)
  • InterPro:IPR010909 (1)
  • InterPro:IPR013273 (1)
  • InterPro:IPR024079 (1)
  • PROSITE:PS50092 (1)
  • PROSITE:PS50215 (1)
  • PROSITE:PS50900 (1)
  • Pfam:PF00090 (1)
  • Pfam:PF01421 (1)
  • Pfam:PF01562 (1)
  • Pfam:PF05986 (1)
  • Pfam:PF08686 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA adamts18-001 (1) 7719
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adamts18 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    adamts18 Contained in: [BAC] DKEY-59H7 (order this), DKEY-273O8 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009303403 (1) 4441 bp
    Genomic GenBank:BX511133 (1) 157916 bp
    Select Tool
    Polypeptide UniProtKB:E7FEJ5 (1) 1244 aa
    Sequence Clusters UniGene:129936 (1)
    Sequence Information (all 9)
    OTHER adamts18 GENE PAGES
  • Gene:100150128 (1)
  • VEGA:OTTDARG00000035316 (1)
  • Ensembl(Zv9):ENSDARG00000001999 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish adamts18 7  
    Human ADAMTS18 16 (16q23)
  • OMIM:607512
  • Gene:170692
  • Mouse Adamts18 8 ( 59.65 cM)
  • MGI:2442600
  • Gene:208936
  • Orthology Details
    CITATIONS (15)