Gene
adamts13
- ID
- ZDB-GENE-070814-7
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 13
- Symbol
- adamts13 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in blood plasma. Human ortholog(s) of this gene implicated in thrombotic thrombocytopenic purpura. Orthologous to human ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zheng et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zheng et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thrombotic thrombocytopenic purpura | Alliance | Thrombotic thrombocytopenic purpura, hereditary | 274150 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000859 | CUB domain |
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR010294 | ADAMTS/ADAMTS-like, Spacer 1 |
| Domain | IPR041645 | ADAMTS, cysteine-rich domain 2 |
| Domain | IPR045371 | ADAMTS/ADAMTS-like, cysteine-rich domain 3 |
| Family | IPR013273 | ADAMTS/ADAMTS-like |
| Family | IPR050439 | ADAMTS and ADAMTS-like |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | CUB domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Spermadhesin, CUB domain superfamily | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PZM1 | InterPro | 1498 | |||||||||||
| UniProtKB:A0A286Y999 | InterPro | 1498 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adamts13-201
(1)
|
Ensembl | 4,345 nt | ||
| mRNA |
adamts13-202
(1)
|
Ensembl | 5,260 nt |
Interactions and Pathways
No data available
Plasmids
No data available