Gene
adamts13
- ID
- ZDB-GENE-070814-7
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 13
- Symbol
- adamts13 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to localize to extracellular matrix. Human ortholog(s) of this gene implicated in thrombotic thrombocytopenic purpura. Orthologous to human ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
thrombotic thrombocytopenic purpura | Alliance | Thrombotic thrombocytopenic purpura, hereditary | 274150 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000859 | CUB domain |
Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
Domain | IPR041645 | ADAM cysteine-rich domain 2 |
Family | IPR013273 | ADAMTS/ADAMTS-like |
Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
Protein | Length | ADAM cysteine-rich domain 2 | ADAMTS/ADAMTS-like | CUB domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Spermadhesin, CUB domain superfamily | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1R2Z7
|
1364 | ||||||||
UniProtKB:A0A286Y999
|
1498 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
adamts13-201
(1)
|
4345 nt |
Interactions and Pathways
No data available
Plasmids
No data available