Gene

adamts9

ID

ZDB-GENE-070814-6

Name

ADAM metallopeptidase with thrombospondin type 1 motif, 9

Symbol

adamts9 Nomenclature History

Previous Names

loc (1)
pimienta locura (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Is predicted to enable metalloendopeptidase activity. Involved in extracellular matrix organization. Acts upstream of or within endocrine pancreas development and pancreas regeneration. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; gonad; immune system; lepidotrichium; and nervous system. Used to study scoliosis. Orthologous to human ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adamts9 Human Ortholog

No data available

Associated With adamts9 Via Experimental Models

Human Disease	Fish	Conditions	Citations
scoliosis	adamts9^{stl316/stl316}	standard conditions	Gray et al., 2020
scoliosis	adamts9^{stl756/stl756}	standard conditions	Gray et al., 2020
scoliosis	adamts9^{stl336/stl336}	standard conditions	Gray et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR002870	Peptidase M12B, propeptide
Family	IPR013273	ADAMTS/ADAMTS-like
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat

Domain Details Per Protein

Protein	Length	ADAMTS/ADAMTS-like	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin	Peptidase M12B, propeptide	Thrombospondin type-1 (TSP1) repeat	Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:F1R6Q4 InterPro	1461
UniProtKB:E7F6N6 InterPro	1443

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	adamts9-201 (1) Ensembl	10402 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations