Gene

adam12b

ID
ZDB-GENE-070809-1
Name
ADAM metallopeptidase domain 12b
Symbol
adam12b Nomenclature History
Previous Names
  • adam12
  • adam12a (1)
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in osteoarthritis. Is expressed in heart tube; intermediate cell mass of mesoderm; lateral plate mesoderm; midbrain; and pharyngeal arch cartilage. Orthologous to human ADAM12 (ADAM metallopeptidase domain 12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Tokumasu et al., 2016
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adam12b Human Ortholog
No data available
Associated With adam12b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018358 Disintegrin, conserved site
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR001762 Disintegrin domain
Domain IPR002870 Peptidase M12B, propeptide
Domain IPR006586 ADAM, cysteine-rich domain
Domain IPR034027 Reprolysin domain, adamalysin-type
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036436 Disintegrin domain superfamily
Domain Details Per Protein
Protein Length ADAM, cysteine-rich domain Disintegrin, conserved site Disintegrin domain Disintegrin domain superfamily Metallopeptidase, catalytic domain superfamily Peptidase M12B, ADAM/reprolysin Peptidase M12B, propeptide Reprolysin domain, adamalysin-type
UniProtKB:X1WHA6 48
UniProtKB:E7FEZ4 924
UniProtKB:A0A0R4INJ8 941
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations