ZFIN ID: ZDB-GENE-070802-4
Gene Name: collagen, type IV, alpha 3
Gene Symbol: col4a3    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have extracellular matrix structural constituent. Predicted to be involved in extracellular matrix organization. Predicted to localize to collagen type IV trimer and extracellular space. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in Alport syndrome; autosomal dominant Alport syndrome; autosomal recessive Alport syndrome; benign familial hematuria; and end stage renal disease. Orthologous to human COL4A3 (collagen type IV alpha 3 chain).
Genome Resources: Alliance (1),  Gene:553354 (1),  Ensembl(GRCz11):ENSDARG00000003395 (2)
Note: Gene characterized by MacDonald et al. (2007) by NC1 domain only.
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
col4a3_unrecovered Point Mutation Unknown Unknown ENU
fh337 Point Mutation Unknown Unknown ENU
sa12489 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22698 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42602 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH col4a3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant Alport syndrome Alliance Alport syndrome 3, autosomal dominant 104200
    autosomal recessive Alport syndrome Alliance Alport syndrome 2, autosomal recessive 203780
    benign familial hematuria Alliance Hematuria, benign familial 141200
    DISEASE ASSOCIATED WITH col4a3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process extracellular matrix organization (more)
    Cellular Component collagen trimer (more)
    Molecular Function extracellular matrix structural constituent (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA col4a3-202 (1)    Ensembl 9477
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM col4a3 No data available
    MARKER RELATIONSHIPS
    col4a3 Contained in: [BAC] DKEY-29L4 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_688921 (1) 5154 nt
    Genomic GenBank:BX571880 (1) 194220 nt
    Select Tool
    Polypeptide UniProtKB:X1WCV8 (1) 1684 aa
    Sequence Information (all 10)
    ORTHOLOGY for col4a3 ( Chr: 15 )
    CITATIONS (23)