Gene

xdh

ID
ZDB-GENE-070719-9
Name
xanthine dehydrogenase
Symbol
xdh Nomenclature History
Previous Names
  • im:7146167
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have flavin adenine dinucleotide binding activity and xanthine dehydrogenase activity. Predicted to be involved in xanthine catabolic process. Predicted to localize to cytosol. Is expressed in neural crest cell and xanthoblast. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; artery disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria. Orthologous to human XDH (xanthine dehydrogenase).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With xdh Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
xanthinuria Alliance Xanthinuria, type I 278300
Associated With xdh Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
Binding_site IPR022407 Oxidoreductase, molybdopterin binding site
Domain IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
Domain IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
Domain IPR002346 Molybdopterin dehydrogenase, FAD-binding
Domain IPR002888 [2Fe-2S]-binding
Domain IPR005107 CO dehydrogenase flavoprotein, C-terminal
Domain IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
Domain IPR014307 Xanthine dehydrogenase, small subunit
Domain IPR014309 Xanthine dehydrogenase, molybdopterin binding subunit
Domain IPR016166 FAD-binding domain, PCMH-type
Family IPR016208 Aldehyde oxidase/xanthine dehydrogenase
Homologous_superfamily IPR012675 Beta-grasp domain superfamily
Homologous_superfamily IPR016167 FAD-binding, type PCMH, subdomain 1
Homologous_superfamily IPR016169 FAD-binding, type PCMH, subdomain 2
Homologous_superfamily IPR036010 2Fe-2S ferredoxin-like superfamily
Homologous_superfamily IPR036318 FAD-binding, type PCMH-like superfamily
Homologous_superfamily IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamily
Homologous_superfamily IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
Homologous_superfamily IPR036884 [2Fe-2S]-binding domain superfamily
Homologous_superfamily IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
Domain Details Per Protein
Protein Length [2Fe-2S]-binding [2Fe-2S]-binding domain superfamily 2Fe-2S ferredoxin, iron-sulphur binding site 2Fe-2S ferredoxin-like superfamily 2Fe-2S ferredoxin-type iron-sulfur binding domain Aldehyde oxidase/xanthine dehydrogenase Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily Beta-grasp domain superfamily CO dehydrogenase flavoprotein, C-terminal CO dehydrogenase flavoprotein, C-terminal domain superfamily FAD-binding domain, PCMH-type FAD-binding, type PCMH-like superfamily FAD-binding, type PCMH, subdomain 1 FAD-binding, type PCMH, subdomain 2 Molybdopterin dehydrogenase, FAD-binding Oxidoreductase, molybdopterin binding site Xanthine dehydrogenase, molybdopterin binding subunit Xanthine dehydrogenase, small subunit
UniProtKB:A0A2R8Q1T4 1381
UniProtKB:E7F022 1351
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations