Gene

dpp6b

ID

ZDB-GENE-070705-88

Name

dipeptidyl-peptidase 6b

Symbol

dpp6b Nomenclature History

Previous Names

si:ch211-198f16.1 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable potassium channel regulator activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dpp6b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 33	Alliance	Intellectual developmental disorder, autosomal dominant 33	616311
		{Ventricular fibrillation, paroxysmal familial, 2}	612956

Associated With dpp6b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001375	Peptidase S9, prolyl oligopeptidase, catalytic domain
Domain	IPR002469	Dipeptidylpeptidase IV, N-terminal domain
Family	IPR050278	Serine protease S9B/DPPIV
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold