ZFIN ID: ZDB-GENE-070705-557
Gene Name: polymerase (DNA directed), epsilon
Gene Symbol: pole
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: si:dkeyp-98c11.2

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have DNA binding activity, DNA-directed DNA polymerase activity, and single-stranded DNA 3'-5' exodeoxyribonuclease activity; predicted to be involved in DNA-dependent DNA replication,  ...
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (13 images) from Thisse et al., 2004 [IMAGE:7165171]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024788Tg Transgenic Insertion Unknown Unknown DNA
sa6963 Point Mutation Unknown Splice Site ENU
sa10893 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26416 Point Mutation Unknown Splice Site ENU
    sa31416 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44601 Point Mutation Unknown Unknown ENU
    t20320 Point Mutation Unknown Missense ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pole HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    FILS syndrome 615139
    {Colorectal cancer, susceptibility to, 12} 615083
    IMAGE-I syndrome 618336
    DISEASE ASSOCIATED WITH pole VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA repair (more)
    Cellular Component epsilon DNA polymerase complex (more)
    Molecular Function 4 iron, 4 sulfur cluster binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006133 (1)
  • InterPro:IPR006134 (1)
  • InterPro:IPR006172 (1)
  • InterPro:IPR012337 (1)
  • InterPro:IPR013697 (1)
  • InterPro:IPR029703 (1)
  • InterPro:IPR036397 (1)
  • Pfam:PF00136 (1)
  • Pfam:PF03104 (1)
  • Pfam:PF08490 (1)
  • EC:2.7.7.7 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pole-001 (1) 7154
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pole No data available
    MARKER RELATIONSHIPS
    poleContained in: [BAC] DKEYP-98C11 (1)
    poleEncodes: [EST] IMAGE:7165171 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128523 (1)
    Genomic GenBank:CT737234 (1) 150194bp
    Select Tool
    Polypeptide UniProtKB:B0V351 (1) 2284aa
    Sequence Clusters UniGene:40806 (1)
    Sequence Information (all 14)
    OTHER pole GENE PAGES
  • Alliance (1)
  • Gene:553405 (1)
  • VEGA:OTTDARG00000024807 (1)
  • ORTHOLOGY for pole (Chr: 5)
    CITATIONS (20)