Community Action Needed: Please respond to the NIH RFI
Gene

pole

ID
ZDB-GENE-070705-557
Name
polymerase (DNA directed), epsilon
Symbol
pole Nomenclature History
Previous Names
  • si:dkeyp-98c11.2
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable DNA binding activity; DNA-directed DNA polymerase activity; and single-stranded DNA 3'-5' exodeoxyribonuclease activity. Predicted to be involved in DNA metabolic process and mitotic cell cycle. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be located in nucleus. Predicted to be part of epsilon DNA polymerase complex. Is expressed in proliferative region. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pole Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
FILS syndrome 615139
IMAGE-I syndrome 618336
{Colorectal cancer, susceptibility to, 12} 615083
Associated With pole Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
Domain IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
Domain IPR013697 DNA polymerase epsilon, catalytic subunit A, C-terminal
Family IPR006172 DNA-directed DNA polymerase, family B
Family IPR029703 DNA polymerase epsilon catalytic subunit
Homologous_superfamily IPR012337 Ribonuclease H-like superfamily
Homologous_superfamily IPR036397 Ribonuclease H superfamily
Homologous_superfamily IPR042087 DNA polymerase family B, C-terminal domain
Homologous_superfamily IPR043502 DNA/RNA polymerase superfamily
Domain Details Per Protein
Protein Length DNA-directed DNA polymerase, family B DNA-directed DNA polymerase, family B, exonuclease domain DNA-directed DNA polymerase, family B, multifunctional domain DNA polymerase epsilon catalytic subunit DNA polymerase epsilon, catalytic subunit A, C-terminal DNA polymerase family B, C-terminal domain DNA/RNA polymerase superfamily Ribonuclease H-like superfamily Ribonuclease H superfamily
UniProtKB:A0A2R8PX42 2276
UniProtKB:B0V351 2284
UniProtKB:A8WFY0 565
UniProtKB:Q561Q1 539
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations